Research on cancer reversal and recovery successes. Highlights from more than 130 clinical studies on repurposed drugs and other successful treatments.

Highlights plus links to published research and evidence of treatment suppression that doesn't benefit establishment medicine.

This curation of research provides quick access to documented cancer reversal and recovery successes.

Because this curation has grown so large, we’ve separated the testimonials and research for easier navigation:

• For a curation of more than 200 medical and personal testimonials, see: Cancer Reversal & Recovery Testimonials & Protocols.

• For more than 130 research highlights and links for verification, see below.

At most, he had six months left, according to his oncologist. Following adding Ivermectin, his tumor markers dropped from 1489 to 4.7, and his metastases calcified and shrunk.

Dr. Justus R. Hope MD

(For more than 200 other testimonials, go here.)

Contents

1. Anti-Parasitics Research

2. Research on Other Successful Treatments

3. Research & Warning: Methylene Blue (Synthetic)

4. Treatment Suppression: Verifiable Evidence

5. Context: See how this subject fits in the bigger picture, and get links to related topics

Anti-Parasitics Research

Ivermectin: Antitumor Effects, Promotes Cancer Death, Nontoxic to Normal Cells, Reverses Multidrug Resistance

Ivermectin effectively suppresses the proliferation and metastasis of cancer cells and promotes cancer cell death at doses that are nontoxic to normal cells. Ivermectin shows excellent efficacy against conventional chemotherapy drug-resistant cancer cells and reverses multidrug resistance… Ivermectin has powerful antitumor effects, including the inhibition of proliferation, metastasis, and angiogenic activity, in a variety of cancer cells… Ivermectin promotes programmed cancer cell death, including apoptosis, autophagy and pyroptosis… Ivermectin can also inhibit tumor stem cells.

Pharmacological Research, 2021

Studies demonstrate that Ivermectin (IVM) inhibits glucose uptake by downregulating GLUT1 transporters and hexokinase II (HKII), key enzymes in the glycolytic cascade. This starves cancer cells of their primary fuel, inducing energy stress and apoptosis. Additionally, IVM disrupts microtubule dynamics halting mitotic spindle formation in rapidly dividing cells. These activities do not materially impact healthy cells that rely on oxygen for its primary fuel, and as they are not rapidly dividing, disrupting the microtubular network does not impact them. (The opposite of chemotherapy, which indiscriminately destroys all cells, and ultimately poisons the patient.) … Fenbendazole (FBZ)… complements IVM by targeting overlapping yet distinct metabolic vulnerabilities… Unlike IVM, FBZ also impairs proteasomal function, amplifying cellular stress and triggering p53-mediated apoptosis in colorectal and lung cancer models. FBZ’s efficacy perfectly aligns with Warburg’s thesis in its capacity to exploit cancer’s glycolytic (sugar) addiction; by curtailing glucose availability, FBZ forces malignant cells into a metabolic cul-de-sac, where compensatory mechanisms falter. Preclinical studies highlight its efficacy against drug-resistant tumors, suggesting a role in overcoming the Cancer Stem Cell driven relapses that plague conventional therapies… Allulose, a rare sugar found naturally in figs is a C-3 epimer of fructose, emerges as a novel adjunct in this metabolic triad… Research illuminates its anticancer potential, aligning with Warburg’s emphasis on glucose deprivation… Mechanistically, allulose inhibits intestinal glucose absorption and promotes urinary excretion, lowering systemic glucose levels without triggering insulin spikes. This metabolic rerouting disrupts the fuel supply to cancer cells, amplifying the effects of both IVM and FBZ.

2nd Smartest Guy in the World

1. Jun 15, 2025 — Scientists Announce Major Breakthrough as Ivermectin Nanoparticles Destroy Brain Cancer Cells — Frank Bergman, SLAY link

2. Mar 31, 2025 — How to Block Cancer Stem Cells: A few specific options with more to follow; “Based on cumulative mechanistic, preclinical, and clinical evidence from the Cancer Care monograph and other sources, the most robust biochemical CSC-targeting agents to date are: Metformin, Curcumin, Disulfiram, Ivermectin, Green Tea Extract (EGCG), and Berberine. However, we should also consider the safety profile of these agents. My understanding is that disulfiram can have significant and severe side effects. The other treatments, especially curcumin and ivermectin, are safe. Some sources suggest that curcumin is not easily absorbed and should be combined with piperine (black pepper extract). We should also always check for possible interactions with any other medications or supplementation we are using.” — Justin Smith link

3. Jan 15, 2025 — Do Ivermectin and Mebendazole help against cancer? Research in different cancers. — Dr. Igor Atabekov (YouTube) 10-min video

4. Jan 12, 2025— BOMBSHELL CURE For Pfizer’s COVID “Vaccine” Integration Into The Human Genome; “The latest research findings support what this Substack has been theorizing for the last few years regarding the miraculous repurposed compounds Ivermectin and Fenbendazole.” — 2nd Smartest Guy in the World link

5. Dec 3, 2024 — Groundbreaking Study on Ivermectin and Fenbendazole in Cancer Treatment; “The research reveals the combined effects of ivermectin, fenbendazole, and complementary compounds in addressing cancer at multiple levels. While traditionally known as antiparasitic drugs, ivermectin and fenbendazole, when used together, showed potential to modulate cancer pathways and support the body’s natural healing mechanisms. Key findings from the study: 1. Immune System Modulation… 2. Cellular Repair… 3. Anti-Cancer Activity… These effects were further amplified by the addition of Vitamin E, curcumin, and CBD, which are known for their anti-inflammatory, antioxidant, and immune supporting properties. This synergy highlights the importance of combining multiple therapeutic elements to address the complexities of cancer biology. Read the full study here to explore the detailed findings.” — Internal Healing & Wellness (Dr. Khan MD, Functional Medicine Doctor in The Woodlands) link

6. Nov 5, 2024 — Ivermectin Inhibits Bladder Cancer Cell Growth and Induces Oxidative Stress and DNA Damage — Ning Fan et al, Anti-Cancer Agents link

7. Oct 14, 2024 — New Cancer Treatment Protocol Featuring ‘Horse Dewormer’ Ivermectin, ‘Dog Dewormer’ Fenbendazole, and Mebendazole Passes Peer Review, Marking Potential Breakthrough in Therapy; “According to the publication, ivermectin, fenbendazole, and mebendazole each exhibit anticancer properties through distinct yet complementary mechanisms. Ivermectin, an antiparasitic agent, induces apoptosis in cancer cells by modulating mitochondrial function and inhibiting critical pathways such as glycolysis. It has shown significant efficacy in shrinking tumor volumes in various cancer types, including pancreatic cancer, when used alone or in combination with other agents. Fenbendazole and mebendazole, originally used as veterinary antiparasitic agents, have shown promise as anticancer agents by disrupting microtubule formation, inhibiting glucose metabolism, and inducing apoptosis specifically in cancer cells. Both drugs have been demonstrated to reduce tumor growth and improve survival in preclinical cancer models, often surpassing traditional chemotherapy in efficacy​.” — Jim Hoft, Gateway Pundit link

8. Sep 19, 2024 — Targeting the Mitochondrial-Stem Cell Connection in Cancer Treatment: A Hybrid Orthomolecular Protocol; “Based on our review of the scientific literature, the following protocol combining orthomolecules, drugs and additional therapies for targeting the mitochondrial-stem cell connection (MSCC) in cancer treatment is proposed: Intravenous Vitamin C… Oral Vitamin D… Zinc… Ivermectin… Benzimidazoles and DON… Dietary Interventions… Additional Therapeutics.” [Dosage considerations included in paper.] — Ilyes Baghli et al, Journal of Orthomolecular Medicine link

9. Mar 20, 2024 — Lipid-Restricted Culture Media Reveal Unexpected Cancer Cell Sensitivities; “Fenretinide and ivermectin [are] small molecules whose cytotoxicity is greatly enhanced in lipid-restricted media formulations. The mechanism of action studies indicates that ivermectin-induced cell death involves oxidative stress… Notably, both fenretinide and ivermectin have previously demonstrated in vivo anticancer efficacy despite their low cytotoxicity [cell toxicity] under typical cell culture conditions.” — Ralson B. Goldfarb et al, ACS Chemical Biology link

10. Mar 12, 2024 — Ivermectin: A Multifaceted Drug With a Potential Beyond Anti-parasitic Therapy; “Ivermectin is a derivative of avermectin originally used to treat parasitic infections. Emerging literature has suggested that its role goes beyond this and may help treat inflammatory conditions, viral infections, and cancers.” — Baneet Kaur et al, Cureus link

11. Jan 26, 2024 — Albendazole inhibits colon cancer progression and therapy resistance by targeting ubiquitin ligase RNF20 — Iram Fatima et al, British Journal of Cancer link

12. Jan 24, 2024 — Gene signatures to therapeutics: Assessing the potential of ivermectin against translocation multiple myeloma; “Ivermectin showed strong binding affinity to all 10 identified targets… Ivermectin inhibited translocation multiple myeloma cell growth… and induced multiple myeloma cell apoptosis in vitro. Furthermore, ivermectin increased reactive oxygen species accumulation and altered the mitochondrial membrane potential in translocation multiple myeloma cells.” — Yang Song et al, World Journal of Clinical Oncology link

13. Oct 14, 2023 — Antiparasitic Drugs Killing Cancer? How does it work? Can it be used by cancer patients?; “A number of drugs against parasites (artemisinin, ivermectin, chloroquine, hydroxychloroquine, albendazole, mebendazole, etc.), which have long been used in humans, have attracted the attention of scientists in recent years. It has been observed that they are also able to attack cancer cells, reducing the resistance of tumors. In this video we will look at what is currently known about the use of antiparasitic drugs against cancer. — Dr. Igor Atabekov, Oncologist 10-min video

14. Oct 10, 2023 — Ivermectin as a potential therapeutic strategy for glioma [tumor on brain or spinal cord]; “This review seeks to provide an overview of the underlying mechanisms that enable ivermectin’s capacity to suppress glioma. Furthermore, it aims to elucidate the challenges and prospects associated with utilizing ivermectin as a new anticancer agent.” — Xing Hu et al, Journal of Neuroscience Research link

15. Oct 3, 2023 — Ivermectin: Wonderdrug; “It has profound anti-cancer properties. How profound? Well, consider the following: Overcomes cancer cell resistance to chemotherapy (read here). Inhibits a protein (PAK1) essential for the growth of more than 70% of all cancers (read here). Multiple mechanisms of action against breast cancer (read here).” — Dr. Michael Turner MD link

16. Sep 23, 2023 — Ivermectin induces nonprotective autophagy by downregulating PAK1 and apoptosis in lung adenocarcinoma cells — Man-Yuan Li et al, Cancer Chemotherapy and Pharmacology link

17. Aug 25, 2023 — Therapeutic targeting of nuclear export and import receptors in cancer and their potential in combination chemotherapy “Ivermectin preclinical/clinical anticancer activity: KPNB1-dependent anti-proliferative and pro-apoptotic effects in epithelial ovarian carcinoma and chronic myeloid leukaemia cell lines. Blocked nuclear import of HIF-1a, thereby downregulating hypoxia-induced tumorigenic transcriptional responses.” — Stella Newell et al, IUBMB Life link

18. Jun 14, 2023 — Ivermectin May Defeat Cancer and Other Common Chronic Diseases of Aging: If you think Big Pharma had good reasons to censor ivermectin during Covid-19 how about now when we know it is likely effective against all chronic diseases associated with aging? — Marian Laderoute PhD (Immunology) link

19. May 12, 2023 — Eprinomectin: a derivative of ivermectin suppresses growth and metastatic phenotypes of prostate cancer cells by targeting the β-catenin signaling pathway — Angela Samy et al, Journal of Cancer Research and Clinical Oncology link

20. Aug 25, 2022 — Ivermectin and gemcitabine combination treatment induces apoptosis of pancreatic cancer cells via mitochondrial dysfunction — Da Eun Lee et al, Frontiers in Pharmacology link

21. Jun 15, 2022 — Abstract 2320: Ivermectin suppresses pancreatic cancer via mitochondria dysfunction — Daeun Lee et al, American Association for Cancer Research link

22. Aug 12, 2021 — Ivermectin has New Application in Inhibiting Colorectal Cancer Cell Growth — Shican Zhou et al, Frontiers in Pharmacology link

23. Aug 3, 2021 — Johns Hopkins Study: Anti-Parasitic Drug Slows Pancreatic Cancer in Mice; “In a study published in the journal Oncotarget on July 6, Gregory Riggins, M.D., Ph.D., professor of neurosurgery and oncology at the Johns Hopkins University School of Medicine, and his team used two different mouse models to determine that the anti-parasitic drug mebendazole could slow or stop the growth and spread of both early and late-stage pancreatic cancer.” — Johns Hopkins Medicine link

24. Jul 6, 2021 — Mebendazole disrupts stromal desmoplasia and tumorigenesis in two models of pancreatic cancer — Tara Williamson et al, Oncotarget link

25. Jun 30, 2021 — Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update; “Two clinical reports for albendazole and 2 case reports for mebendazole have revealed promising effects of these drugs in human patients having variable types of cancers. However, because of the toxicity of albendazole… mebendazole is currently more popularly used than albendazole in anti-cancer clinical trials.” — Jony-Yil Chai et al, The Korean Journal of Parasitology link

26. June 2021 — Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update; “It is of particular note that albendazole and mebendazole have been repositioned as promising anti-cancer drugs. These drugs have been shown to be active in vitro and in vivo (animals) against liver, lung, ovary, prostate, colorectal, breast, head and neck cancers, and melanoma… However, because of the toxicity of albendazole… if high doses are used for a prolonged time, mebendazole is currently more popularly used than albendazole in anti-cancer clinical trials.” — Jong-Yil Chai et al, The Korean Journal of Parasitology link

27. Apr 29, 2021 — Repositioning of Antiparasitic Drugs for Tumor Treatment; “Based on the similarities between parasitic diseases and cancer, recent studies aimed to investigate the efficacy of existing antiparasitic drugs in cancer…. These drugs regulate tumor growth via multiple targets, pathways, and modes of action. These antiparasitic drugs are good candidates for comprehensive, in-depth analyses of tumor occurrence and development.” — Yan-Qi Li et al, Frontiers in Oncology link

28. Mar 18, 2021 — Albendazole exerts antiproliferative effects on prostate cancer cells by inducing reactive oxygen species generation — Ukjin Kim et al, Oncology Letters link

29. Mar 2, 2021 — Ivermectin converts cold tumors hot and synergizes with immune checkpoint blockade for treatment of breast cancer — Dobrin Draganov et al, NPJ Breast Cancer link

30. Feb 10, 2021 — Fenbendazole Enhancing Anti-Tumor Effect: A Case Series — Ryan S. Chiang et al, Clinical Oncology: Case Reports link

31. January 2021 — Ivermectin, a potential anticancer drug derived from an antiparasitic drug; “Ivermectin effectively suppresses the proliferation and metastasis of cancer cells and promotes cancer cell death at doses that are nontoxic to normal cells. Ivermectin shows excellent efficacy against conventional chemotherapy drug-resistant cancer cells and reverses multidrug resistance.” — Mingyang Tang et al, Pharmacological Research link

32. Jan 21, 2020 — Progress in Understanding the Molecular Mechanisms Underlying the Antitumour Effects of Ivermectin — Jian Liu et al, Drug Design, Development and Therapy link

33. Jun 18, 2019 — Ivermectin reverses the drug resistance in cancer cells through EGFR/ERK/Akt/NF-κB pathway; “Ivermectin significantly enhanced the anti-cancer efficacy of chemotherapeutic drugs to tumor cells, especially in the drug-resistant cells.” — Lu Jiang et al, Journal of Experimental & Clinical Cancer Research link

34. Aug 31, 2019 — Mebendazole as a Candidate for Drug Repurposing in Oncology: An Extensive Review of Current Literature; “Several in vitro studies suggest that mebendazole (MBZ) inhibits a wide range of factors involved in tumor progression… MBZ not only exhibits direct cytotoxic activity, but also synergizes with ionizing radiations and different chemotherapeutic agents and stimulates antitumoral immune response. In vivo, MBZ treatment… led to the reduction or complete arrest of tumor growth, marked decrease of metastatic spread, and improvement of survival.” — Andrea Emanuele et al, Cancers link

35. Aug 12, 2018 — Cytotoxic Effect of Albendazole on the Breast Cancer and Melanoma Cell Lines; “Albendazole significantly reduced the viability of MCF7 [a “breast cancer cell line”]… In addition, this effect on B16F10 [“the melanoma cell line”] in all Albendazole concentration levels was significant.” — Spideh Javdan et al, Zahedan Journal of Research in Medical Sciences link

36. Apr 20, 2017 — Repurposing Albendazole: new potential as a chemotherapeutic agent with preferential activity against HPV-negative head and neck squamous cell cancer; “Albendazole treatment resulted in apoptosis, inhibition of cell migration, cell cycle arrest in the G2/M phase and altered tubulin distribution. Normal control cells were not measurably affected by any dose tested. This study indicates that albendazole acts to inhibit the proliferation of human papillomavirus-negative HNSCC cell lines.” — Farhad Ghasemi et al, Oncotarget link

37. Sep 22, 2016 — Albendazole as a promising molecule for tumor control — L.S.E.P.W. Castro et al, Redox Biology link

38. Feb 10, 2011 — Ivermectin, ‘Wonder Drug’ from Japan: The Human Use Perspective; “Originally introduced as a veterinary drug, it kills a wide range of internal and external parasites in commercial livestock and companion animals. It was quickly discovered to be ideal in combating two of the world’s most devastating and disfiguring diseases which have plagued the world’s poor throughout the tropics for centuries. It is now being used free-of-charge as the sole tool in campaigns to eliminate both diseases globally. It has also been used to successfully overcome several other human diseases and new uses for it are continually being found. This paper looks in depth at the events surrounding ivermectin’s passage from being a huge success in Animal Health into its widespread use in humans, a development which has led many to describe it as a ‘wonder’ drug.” — Andry Crump & Satoshi Omura, Proceedings of the Japan Academy link

Research on Other Successful Treatments

No Date

1. How Vitamin D Stops Cancer Stem Cells; “Roughly 10,000 cancer cells are generated by the body every single day. One of the most common factors contributing to the ability of these cancer stem cells to proliferate and invade new tissue is D3 deficiency… 1,000,000 participants were analyzed in one single study that found an association between high calcitriol concentration and a low incidence of colorectal cancer. In other words, there is an inverse relationship between the concentration of vitamin D and the risk for colon and rectal cancer. Data shows that for every 10 ng/ml decrease of vitamin D in a person’s blood, there is a significantly increased risk of colorectal cancer for that individual… The use of calcitriol to both inhibit the growth of prostate cancer cells but also their progression is validated in multiple studies… In vitro studies suggest that D3 enables the ability of GcMAF to attack and eradicate human breast cancer cells… Other evidence for alternative cancer therapy using the Swiss Protocol supports that D3 and GcMAF may be a powerful duo that removes a breast cancer activator oncogene known as Her-2.” — Dr. David Jockers link

2. Zinc Deficiency Symptoms and Best Food Sources; “Zinc’s modulatory effect on NF-kB makes it a formidable player in the prevention of cancer cell growth patterns. It has been shown to decrease tumor cell angiogenesis and the induction of inflammatory cytokines. It also increases apoptosis (programmed cell death) in abnormal cell lines which reduces the chances of cancer growth. Research shows that zinc is particularly important in prostate and breast cancers. A 2012 study showed that individuals with BRCA1 gene (strongly associated with breast cancer development) that had the highest levels of zinc had the lowest risk of cancer development. The study also showed that those with the lowest zinc levels had a significantly elevated risk of developing breast cancer. — Dr. David Jockers link DCA for cancer treatment; “DCA disrupts the chemical reactions that tumors use for their rapid growth, starving cancerous cells of nutrients. Moreover… DCA is an activator of damaged mitochondria… [and] increases the production of reactive oxygen species in the cell. These changes induce further cellular mechanisms that lead to apoptosis, which is selective tumor cell death. This results in decreased proliferation of cancer cells, decreased tumor size, symptom alleviation and increased host survival.” — DCA Guide link

3. How Sugar Feeds Cancer Growth; “Cancer cells are metabolically damaged… their energy producing structures, mitochondria, are unable to operate efficiently. This manifests in their preference for glucose as a fuel source, relatively low-yield production of ATP, and rampant production of oxidative species. Normal healthy cells, on the other hand, are able to exhibit metabolic flexibility where they can burn multiple sources of fuel, produce more ATP, and relatively lower levels of oxidative species… Cancer cells, even in the presence of oxygen, choose to undergo glycolysis utilizing glucose (and sometimes glutamine) as the favored substrate. This is the more scientific understanding of how sugar feeds cancer… As long as it is abundant in the blood, sugar feeds cancer growth in a way that will only promote its development… Therefore, reducing sugar intake, getting the body into a state of ketosis, and implementing intermittent fasting can be powerful cancer-fighting strategies. Because cancer cells in general are metabolically inflexible, we are able to take advantage of ketone metabolism as a way of placing cancer cells in a weakened state. Not only does this make these strategies powerful stand-alone healing practices, but it also improves the outcomes of traditional treatments.” — Dr. David Jockers link

4. Top 12 Cancer Stem Cell Killing Nutrients; [See article for summaries and research on each nutrient. Here we highlight one:] “Each day the body produces approximately 10,000 cancer cells which can invade, proliferate, and spread. One of the most common factors involved in the pathogenesis of cancer is vitamin D₃ deficiency. Receiving adequate amounts of vitamin D₃ daily is necessary to destroy cancer stem cell activity. A supplemental dosage of 20,000 I.U. vitamin D₃ daily may be a reliable therapy to slow the progression of cancer and reduce systemic inflammation. Vitamin D₃ supplementation is perhaps most vital in its need for proper GcMAF production. GcMAF is a protein that improves the natural immune system response and treats cancer. GcMAF requires a steady intake of vitamin D₃ to eradicate tumors completely.” — Dr. David Jockers link

5. 10 Ways Turmeric Benefits the Fight Against Chronic Disease; “Curcuminoids target ten factors involved in cancer development. This includes chronic inflammation, DNA damage and disruption of cell signaling pathways. Curcumin supplementation was shown to target destruction of cancer cell mitochondria, disrupt the cancer cell cycle and arrest stem cell development that facilitates further cancer cell formation. There are hundreds of other studies that have shown that curcumin turns on natural apoptotic (cell suicide) switches in cancer cells. They also reduce inflammatory prostaglandins that promote cancer cell growth. A study out of China showed that curcumin was able to induce apoptosis within triple negative breast cancer (TNBC) cells. TNBC is a type of cancer that defies conventional chemotherapy and radiation.” — Dr. David Jockers link

6. Cancer Cures Video: Video Documentary Reveals Suppressed Cancer Cures [This link is to an article about the documentary, Cancer: The Forbidden Cures] — WantToKnow link

7. Cancer Cures Video; Cancer: The Forbidden Cures — WantToKnow 5-min video,20-min video, full 72-min video

By Date

1. Apr 15, 2025 — Gut Microbes Release Cancer-fighting Bile Acids that Block Hormone Signals; “Bacteria naturally present in the human intestine, known as the gut microbiota, can transform cholesterol-derived bile acids into powerful metabolites that strengthen anti-cancer immunity by blocking androgen signaling, according to a preclinical study led by Weill Cornell Medicine investigators… Primary bile acids are produced by the liver and released into the gut, where diverse groups of bacteria work together to modify their chemical structures.” — Weill Cornell Medicine link

2. Apr 15, 2025 — Microbiota-derived bile acids antagonize the host androgen receptor and drive anti-tumor immunity; “A subset of these microbiota-derived bile acids (BAs) are potent antagonists of the human androgen receptor (hAR). They inhibit AR-related gene expression and are human-relevant. As a proof-of-principle, we demonstrate that one of these BAs suppresses tumor progression and potentiates the efficacy of anti-PD-1 treatment in an AR-dependent manner.” — Wen-Bing Jin et al, Cell link

3. Apr 12, 2025 — The Forgotten Cancer Cure Hiding in Plain Sight: How DMSO turns a common dye into a highly potent cancer treatment that's harmless to normal tissue; “DMSO is a safe and naturally occurring substance that is remarkably effective for a wide range of diseases including pain, injuries, and strokes. DMSO effectively dissolves a variety of medications and can transport them throughout the body. This increases their potency, makes it possible to administer them through the skin, and allows them to target things deep within the body (e.g., resistant infections) that other therapies have difficulty reaching. Through various mechanisms, DMSO selectively targets cancer cells and simultaneously mitigates the consequences of cancer therapies. It also brings conventional and natural cancer therapies to tumors, thereby significantly increasing the potency of these therapies (while simultaneously allowing a much lower and less toxic dose to be used). When DMSO is combined with hematoxylin (a dye widely used in pathology), it becomes a highly potent cancer treatment, both harnessing DMSO’s intrinsic anticancer properties and directly destroying cancer cells. It is also highly specific to targeting cancers while not affecting normal cells, thereby allowing it to dissolve cancers at doses that have virtually no toxicity to the patient.” — A Midwestern Doctor link

4. Apr 7, 2025 — This Week with Dr. T, with special guest, Dr. Orlando E. Silva; “Dr. Silva has extensive knowledge of insulin potentiation therapy (IPT)—a treatment that uses insulin to increase the effectiveness of chemotherapy while reducing toxic side effects.” — Dr. Sherri Tenpenny link

5. Apr 4, 2025 — Beta-Glucans — Nature’s Immune Booster You Need to Know About; “Beta-glucans are natural compounds found in foods like oats, mushrooms and barley that significantly enhance immune function by activating dendritic cells… Research shows beta-glucans fight infections by stimulating immune cells and have impressive anticancer properties, shrinking tumors by up to 95% in studies.” — Dr. Joseph Mercola link

6. Mar 31, 2025 — How to Block Cancer Stem Cells: A few specific options with more to follow; “Based on cumulative mechanistic, preclinical, and clinical evidence from the Cancer Care monograph and other sources, the most robust biochemical CSC-targeting agents to date are: Metformin, Curcumin, Disulfiram, Ivermectin, Green Tea Extract (EGCG), and Berberine. However, we should also consider the safety profile of these agents. My understanding is that disulfiram can have significant and severe side effects. The other treatments, especially curcumin and ivermectin, are safe. Some sources suggest that curcumin is not easily absorbed and should be combined with piperine (black pepper extract). We should also always check for possible interactions with any other medications or supplementation we are using.” — Justin Smith link

7. Mar 25, 2025 — More cancer treatment miracles: 3 amazing new stories thank G-d, using winning protocols of repurposed drugs & supplements: It’s YOUR life. Don’t be afraid to try to live. You don’t need your doctor’s permission to save your life.; “I run an information and support group for cancer patients, which currently has over 750 members. We focus most on the protocols of oncologist Dr. William Makis and of researcher Randy Howe, and on Valasta. I would like to share three wonderful miracle stories… To join the WhatsApp group, here is the link: https://chat.whatsapp.com/KeGxb1et09xJgexoGU2191”— Brucha Weisberger link

8. Mar 17, 2025 — TESTIMONIAL with CLL LEUKEMIA - Case Report of Unexpectedly Long Survival of Patient With Chronic Lymphocytic Leukemia, with Integrative Methods; 2018 Haskin et al - Case Report of Unexpectedly Long Survival of Patient With Chronic Lymphocytic Leukemia: Why Integrative Methods Matter; “I think this CLL patient could have benefited from Ivermectin, Fenbendazole and Mebendazole. What kept her stable? Vitamin D, Green Tea Extract, Curcumin, Milk Thistle - I use all of these. Safflower and Flax Oil (I don’t use this). Inhibits NFkB but Ivermectin does also and it’s significantly stronger. By the way, Milk Thistle is not only a protector for liver toxicity in cancer treatment, it has its own anti-cancer activity as well.” — Dr. William Makis MD link

9. Mar 15, 2025 —Hundreds of Studies Show DMSO Transforms the Treatment of Cancer; “DMSO inhibits cancer growth and consistently reverts cancer cells to their normal state. DMSO enhances cancer visibility to immune cells, enabling the body to eliminate tumors previously undetected by the immune system.

   DMSO effectively mitigates major challenges in conventional cancer care, such as radiation damage, chemotherapy toxicity, and pain from "incurable" metastatic cancer. DMSO markedly boosts the efficacy of many chemotherapy drugs, allowing safer, lower doses to achieve the same results. When paired with certain natural therapies, DMSO often produces highly effective cancer treatments, revolutionizing cancer care.” — A Midwestern Doctor link

10. Mar 15, 2025 — Manuka and Ohia Lehua Honeys Offer Unique Therapeutic Benefits; “Research shows Manuka honey selectively inhibits breast cancer cell growth while leaving healthy cells unharmed, working through multiple mechanisms” — Dr. Joseph Mercola link

11. Mar 12, 2025 — UPDATE MEGADOSAGE PROTOCOL: IVERMECTIN and FENBENDAZOLE Testimonial - 57 Year Old Man With Stage 4 Pancreatic Cancer Sees 87% Drop in CA19.9 From 10951 To 1438! — 2nd Smartest Guy in the World link

12. Mar 10, 2025 — Revolution Cancer Stem Cell Therapy — CMNNews link

13. Mar 10, 2025 — The Simple Routine That Slashes Your Cancer Risk by 60% [Highlights research, the metabolic underpinning of cancer, and Dr. Paul Marik’s cancer control protocol.] — The Vigilant Fox link

14. Mar 10, 2025 — This Simple Well-Researched Habit Cuts Cancer Death Risk By Nearly 50%; “Conducted over 13 years, the research highlights the powerful link between physical activity and lower rates of cancer progression and mortality.” — Ava Durgin, MindBodyGreen link

15. Mar 8, 2025 — The Antidepressant Properties of Lycopene; “Lycopene demonstrates significant anticancer effects against multiple types of cancer, including pancreatic, ovarian, cervical, and liver cancers.” — Dr. Joseph Mercola link

16. Mar 7, 2025 — Metabolic Therapies: Reclaiming Cancer’s Achilles’ Heel Through The Ivermectin, Fenbendazole, and Allulose Revolution; “The Warburg effect — Otto Warburg’s seminal observation that cancer cells preferentially ferment glucose into lactate even in oxygen-rich conditions — represents a metabolic vulnerability ripe as the perfect therapeutic target for cancer treatment.” — 2nd Smartest Guy in the World link

17. Mar 6, 2025 — Cancer Revolution! — Dr. Michael Turner MD link

18. Mar 3, 2025 — Dietary fibre counters the oncogenic potential of colibactin-producing Escherichia coli in colorectal cancer — Bhupesh Kumar Thakur et al, Nature link

19. Feb 25, 2025 — A Victory for INTEGRATIVE PATHWAYS TO HEALTH (IP2H) Medicine: A Novel Approach to Beating Stage IV Triple-Negative Breast Cancer; “A young woman diagnosed with stage IV triple-negative breast cancer, an aggressive and historically untreatable form of the disease, achieved a complete clinical, radiological, and pathological response using an unconventional yet rational treatment strategy. This case study [was] published in Cureus … At the core of this treatment was a novel synergy of Metabolically Supported Chemotherapy, a Ketogenic Diet, Hyperthermia, and Hyperbaric Oxygen Therapy—each selected to exploit fundamental vulnerabilities of cancer cells.”— James Lyons-Weiler PhD link

20. Feb 8, 2025 — The Remarkable Anti-Cancer Potential of Mushrooms: Biological mechanisms, epidemiological evidence, and clinical data support the use of mushrooms in cancer prevention and treatment. — Nicolas Hulscher, MPH link

21. Feb 6, 2025 — Miraculous Cancer Testimonials, Recording of Interview with Researcher Randy Howe about his Lifesaving Protocol, and 246 Scientific Articles to back up his recommended treatments — Brucha Weisberger link

22. Feb 5, 2025 — Revolutionizing Cancer Treatment with Chlorine Dioxide Therapy; [I] designed an intratumoral chlorine dioxide therapy specifically for cancer patients… offered in clinics across several countries, including Germany, Mexico, Brazil, and the Philippines, under licensing agreements… One case involved a Dutch cancer patient with multiple liver and lung tumors. Here is what the therapy achieved… Ultrasound imaging immediately after the injection showed significant tumor necrosis, with clearly defined and reduced tumor borders… Although unexpected within the timeframe, early assessments suggested noticeable shrinkage… The patient reported feeling generally well post-treatment with no major discomfort. These observations highlight how chlorine dioxide can: Destroy cancer cells rapidly through oxidation. Cut off tumor blood supply, inducing extensive necrosis. Reduce inflammation to promote systemic health and minimize the risk of metastasis. Foster tissue healing and regeneration after tumor clearance.” — Xuewu Liu link

23. Jan 27, 2025 — Modified Citrus Pectin Halts Prostate Cancer Progression — Dr. William Makis MD link

24. Jan 26, 2025 — TOCOTRIENOL (Vitamin E) TESTIMONIAL – Dr. Joseph Keenan OF U of Minnesota talks about curing his Non-Hodgkin’s Lymphoma (Follicular) — Dr. William Makis MD link

25. Jan 22, 2025 — Melissa Jolly Graves: Healed terminal cancer (neuroblastoma) holistically; “Melissa Jolly Graves was diagnosed with cancer (neuroblastoma) in 2020 which is a deadly and aggressive cancer. Typically a cancer of children, doctors did not know how to deal with it as it presented in Melissa as an adult. She became very sick and started going through paralysis, losing mental capabilities, losing the ability to walk and having to use a walker. She could not wake up at points, and her family would have to shake her for 45 minutes at a time for her to regain consciousness. The disease went to her brain, it affected her liver, her back, her adrenals, her pituitary gland, her thyroid, her hypothalamus. Her body was shutting down and she felt completely helpless. Melissa was not used to being on the receiving end of treatment, as an energy practitioner and nurse and it was a huge journey to expand her understanding of health and spirituality, heal from trauma and use natural medicine (herbs and supplements), plant based whole food nutrition and many healing modalities…to recover and not only did she recover from neuroblastoma with normal labs and increased vitality, but she also healed herself of scoliosis, diverticulitis, colitis and chondrosis… ‘It’s with great pride and honor that I share my latest labs with you all. 3 years of hard work, going against medical advice, listening to my own intuition, healing with herbs, oxygen, Cryotherapy, red light, sweat lodges, fever baths, HIGH dose of vitamins C, weeding through my mind, and transformation of spirit. No surgery, no chemotherapy, no medical prescription, just me, God, and all you who mentally, physically, and spirituality supported me.” — Health Alliance Australia link

26. Jan 21, 2025 — Breast Cancer and Iodine: How to Prevent and How to Survive Breast Cancer (2001) By Dr David Derry; "Cancer development occurs in two distinct phases - an iodine-controlled phase up to carcinoma in situ, and a thyroid hormone-controlled phase governing cancer spread through connective tissue. This understanding explains why some populations have high early-stage cancer rates but low invasive cancer rates… Despite having the highest rates of thyroid carcinoma in situ (34%), Japanese populations have the world's lowest rates of clinical thyroid, breast, and prostate cancer, attributed to their high iodine intake (8-10 mg daily) through seaweed consumption… Fibrocystic breast disease, affecting 95% of Western women to some degree, represents a precursor state that responds to iodine supplementation. Adequate iodine intake could potentially reduce breast cancer rates to Japanese levels… Japanese migration studies show cancer rates matching host country levels by the second or third generation, demonstrating dietary rather than genetic factors determine cancer risk… Patient well-being and constitutional health, largely controlled by thyroid hormone, significantly influence cancer treatment outcomes but are often overlooked in modern protocols." — Lies are Unbekoming link

27. Jan 12, 2025 — When Ivermectin & Fenbendazole Aren’t Enough – Part 3: AI’s Advice on P53 Enhancement & Targeting Cancer Stem Cells — Dr. Justus R. Hope MD link

28. Jan 7, 2025 — Association between recorded physical activity and cancer progression or mortality in individuals diagnosed with cancer in South Africa; “Individuals engaging in any level of recorded physical activity showed a reduced risk of cancer progression or mortality than those not physically active. There was a further reduction among individuals with moderate to high levels of physical activity compared with those with lower levels. — Ntokozo Mabena et al, British Journal of Sports Medicine link

29. Jan 1, 2025 — Ranking the Top 19 Terminal Cancer Repurposed Drugs; “Artificial Intelligence is singing the praises of Ivermectin and Fenbendazole as evidence-supported treatment for metastatic cancer.” [Includes Albenazole, Melatonin, Green Tea (EGCG), Hydroxychloroquine, Chloroquine, Doxycycle, Resveratrol, Propranolol, Cimetidine, Metform, Lenalidomide, Annatto, CBD oil, Vit E, Vit D.] — Dr. Justus R. Hope MD link

30. Dec 28, 2024 — When Ivermectin & Fenbendazole Aren’t Enough – Part II: Dr. Marik’s Game Changer in Targeting Cancer Stem Cells — Justus R. Hope link

31. Dec 23, 2024 — When Ivermectin & Fenbendazole Aren’t Enough: Fine Tuning Cancer Care with Thomas Seyfried & Kevin Hennings — Justus R. Hope link

32. Dec 5, 2024 — NEWS: Pancreatic Cancer patient survival doubled with high dose of common vitamin (Vitamin C IV Infusions), study finds — Dr. William Makis MD link

33. Dec 3, 2024 — Groundbreaking Study on Ivermectin and Fenbendazole in Cancer Treatment; “The research reveals the combined effects of ivermectin, fenbendazole, and complementary compounds in addressing cancer at multiple levels. While traditionally known as antiparasitic drugs, ivermectin and fenbendazole, when used together, showed potential to modulate cancer pathways and support the body’s natural healing mechanisms. Key findings from the study: 1. Immune System Modulation… 2. Cellular Repair… 3. Anti-Cancer Activity… These effects were further amplified by the addition of Vitamin E, curcumin, and CBD, which are known for their anti-inflammatory, antioxidant, and immune supporting properties. This synergy highlights the importance of combining multiple therapeutic elements to address the complexities of cancer biology. Read the full study here to explore the detailed findings.” — Internal Healing & Wellness (Dr. Khan MD, Functional Medicine Doctor in The Woodlands) link

34. Nov 21, 2024 — High-Dose Vitamin C Doubles Pancreatic Cancer Patient Survival Rates: Clinical Trial: Life expectancy with chemotherapy alone is eight months, while adding high-dose intravenous vitamin C resulted in 16 months of survival. — Cara Michelle Miller, The Epoch Times link

35. Nov 11, 2024 — High-dose IV vitamin C plus chemotherapy doubles survival in advanced pancreatic cancer; “Results from a randomized, phase 2 clinical trial show that adding high-dose, intravenous (IV) vitamin C to chemotherapy doubles the overall survival of patients with late-stage metastatic pancreatic cancer from eight months to 16 months.” — Jennifer Brown, IOWA Healthcare link

36. Nov 2024 — A randomized trial of pharmacological ascorbate, gemcitabine, and nab-paclitaxel for metastatic pancreatic cancer; High dose, intravenous, vitamin C “infusions of 75 g three times weekly in patients with metastatic pancreatic cancer prolongs overall and progression free survival without detriment to quality of life or added toxicity.” — Kellie L. Bodeker, et al, Science Direct link

37. Oct 7, 2024 — The Cancer Expert: “This Common Food Is Making Cancer Worse”; “Dr Thomas Seyfried is a Professor of biology, genetics, and biochemistry… He has over 150 peer-reviewed publications and is also the author of books such as, ‘Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer’. — The Diary of a CEO, YouTube 1.5-hr video

38. Sep 23, 2024 — Melatonin Kills Cancer: Reverses Warburg Effect & Inhibits Glucose — Dr. Casey Peavler, The Functional Medicine Doc 20mn video

39. Sep 19, 2024 — Targeting the Mitochondrial-Stem Cell Connection in Cancer Treatment: A Hybrid Orthomolecular Protocol; “Orthomolecular Medicine for Targeting the mitochondrial-stem cell connection MSCC [includes] vitamin C… vitamin D… zinc… pharmaceutical agents… Ivermectin… Benzimidazoles… Fasting… Ketogenic Diet and Ketone Metabolic Therapy… [and] additional therapeutic considerations…” [Dosage considerations included in paper.] — Ilyes Baghli et al, Journal of Orthomolecular Medicine link

40. Sep 8, 2024 — CBD OIL Curing Lung Cancer – another case of an 81 year old man cured of Stage IIIB Lung Cancer published in 2019 — Dr. William Makis MD link

41. Jul 22, 2024 — Manuka Honey Inhibits Human Breast Cancer Progression in Preclinical Models — Diana C. Marquez-Garban et al, Nutrients link

42. Jun 8, 2024 — Lycopene: A Potent Antioxidant with Multiple Health Benefits; “The ingestion of tomatoes and tomato-based products has been associated with a reduced occurrence of different types of cancer. In vivo and in vitro research has demonstrated that lycopene hinders the growth and multiplication of prostate cancer cells, inhibits the cell cycle, and induces apoptosis. Dietary supplementation with lycopene mitigated the growth of breast cancer cells by suppressing the activity of the insulin-like growth factor 1 receptor (IGF-1R) signalling pathway. While research shows that the consumption of a lycopene-rich diet could be beneficial in reducing the risk of pancreatic cancer. In a rat model, the consumption of lycopene has shown to reduce the progression and proliferation of ovarian cancer, and in human studies, cisplatin-based chemotherapy in combination with lycopene supplementation enhanced cervical cancer treatment. Furthermore, in animal models of hepatocellular carcinoma, administered lycopene suppressed the onset and development of cancer. In human colorectal adenocarcinoma cell line, treatment with lycopene has shown to exhibit genotoxicity, antiproliferative, and apoptotic effects, a demonstration of its anticancer effects. — Mercy Omoye Shafe et al, Journal of Nutrition and Metabolism link

43. Jun 1, 2024 — FASTING and CANCER – New Research on a potential Revolution in Cancer Treatment – What’s best? Periodic fasting (3 days) vs Ketogenic Diet vs Caloric Restriction – 5 major papers reviewed — Dr. William Makis MD link

44. May 9, 2024 — From Hollywood to Beating Breast Cancer w/ Samantha Harris — Dr. Will Cole 3-min video and link

45. Apr 4, 2024 — 100% Cancer Remission Achieved in ALL Patients in Groundbreaking Study: “It’s absolutely incredible … We’ve certainly never seen this before.”; “A recent study published in The New England Journal of Medicine has yielded groundbreaking results after a monoclonal antibody successfully eradicated rectal cancer in all enrolled patients, ushering them into complete remission without resorting to chemotherapy, radiation, or surgical interventions.” — The Vigilant Fox link

46. Apr 3, 2024 — Cancer Eradicated in Every Patient Using Monoclonal Antibody Treatment: Resurfaced ‘New England Journal of Medicine’ Publication: Successful treatment meant patients avoided chemoradiotherapy and surgery. — Jon Fleetwood link

47. Mar 7, 2024 — A Novel Theory on Breast Cancer and Exercise; “One meta-analysis examined 16 studies that found a significant reduction in early-stage breast cancer from exercise. Any exercise at all has been found to be beneficial against breast cancer, even with as little as an hour per week of walking. Benefits were regardless of type of exercise, intensity, or menopausal status. The effect of exercise against breast cancer was shown in a meta-analysis of 42,602 women to beneficially impact survival whether the exercise was done before or after diagnosis. A linear dose-response was shown, in which the more physical activity events, the more survival. The correlation was so strong across all studies that irrefutable causation was established between exercise and breast cancer survival.” — Colleen Huber, The Epoch Times link

48. Feb 1, 2024 — Ultra-processed Foods: Increased Risk of Cancer; “A large-scale prospective cohort study based in Europe examined the data of more than 500,000 people to examine the link between ultra-processed foods and cancer. After adjusting for several factors, including sex, smoking, education, physical activity, height, and diabetes, the results, published in 2023 in the Lancet, showed that “a substitution of 10% of processed foods with an equal amount of minimally processed foods was associated with reduced risk of overall cancer, head and neck cancers, esophageal squamous cell carcinoma, colon cancer, rectal cancer, hepatocellular carcinoma, and postmenopausal breast cancer.” — Mikaela Conley, U.S. Right to Know link

49. Jan 3, 2024 — Aspirin: On Cancer; “Prof. Elwood and colleagues published a paper in September 2022 showing extensive evidence supporting the prediction that aspirin's effects on biological mechanisms involved in cancer growth and spread leads to reduced cancer progression and mortality. A key mechanism is enhancing DNA repair. DNA errors can lead to cancer, and aspirin helps detect and fix these errors in cells.” — Lies are Unbekoming link

50. Nov 24, 2023 — How I Used Vitamin C to Treat My Cancer Patient; “Dr. Monti delves into a liver cancer case that had metastasized to one of the patient’s ribs… Dr. Monti had just initiated a clinical trial for treating metastatic liver cancer with high-dose vitamin C infusions. Laboratory and animal data had suggested that vitamin C at a pharmacological dose could be lethal to that type of cancer cell. Once they gave the patient the infusion, the results were something his team had never seen before. The patient experienced a reversal of the bony metastasis.” — The Dr. Monti Show link and 9-min video

51. Oct 10, 2023 — Immune Combination Therapy Helps Patients With Advanced Liver Cancer Recover — Ying Cheung, The Epoch Times link

52. Oct 5, 2023 — DOXYCYCLINE and CANCER: At Least 12 Anti-Cancer Mechanisms of Action — 2nd Smartest Guy in the World link

53. Nov 14, 2022 — Aspirin and cancer: the emerging evidence; “There is a remarkable harmony between the effects of aspirin on the biological mechanisms of cancer metabolism and growth, and clinical evidence of reductions in cancer mortality and metastatic cancer spread. Although aspirin increases the number of bleeds, the severity of bleeds attributable to aspirin is low, and the risk-benefit balance of aspirin appears to be favourable to aspirin.” — Professor Peter Elwood, Cardiff University School of Medicine (YouTube) 54-min video

54. Oct 25, 2022 — The Rationality of Implementation of Dimethyl Sulfoxide as Differentiation-inducing Agent in Cancer Therapy; “Besides the documented robust differentiation-inducing activities, DMSO has also demonstrated several anti-cancer properties that could further benefit cancer patients, including suppressing proliferation and inducing apoptosis.” — Ba X. Hoang et al, Cancer Diagnosis & Prognosis link

55. Oct 15, 2022 — Ivermectin inhibits tumor metastasis by regulating the Wnt/β-catenin/integrin β1/FAK signaling pathway; “Ivermectin was capable of suppressing tumor metastasis…” — Lu Jiang et al, American Journal of Cancer Research link

56. Jun 8, 2022 — Colorectal Cancer Study with This Amazing Drug; “drug is a monoclonal antibody” — Drbeen Medical Lectures 42-min video

57. Jun 5, 2022 — A Cancer Trial’s Unexpected Result: Remission in Every Patient; “It was a small trial, just 18 rectal cancer patients, every one of whom took the same drug [dostarlimab, monclonal antibody]. But the results were astonishing. The cancer vanished in every single patient, undetectable by physical exam, endoscopy, PET scans or M.R.I. scans.” — Gina Kolata, New York Times link

58. Jun 5, 2022 — PD-1 Blockade in Mismatch Repair–Deficient, Locally Advanced Rectal Cancer; “A total of 12 patients have completed treatment with dostarlimab [monoclonal antibody] and have undergone at least 6 months of follow-up. All 12 patients had a clinical complete response, with no evidence of tumor… At the time of this report, no patients had received chemoradiotherapy or undergone surgery, and no cases of progression or recurrence had been reported during follow-up (range, 6 to 25 months). No adverse events of grade 3 or higher have been reported.” — Dr. Andrea Cercek MD et al, The New England Journal of Medicine link

59. May 2022 — Immunomodulatory effect of mushrooms and their bioactive compounds in cancer: A comprehensive review — Manash Pratim Pathak, et al, Science Direct link

60. Apr 24, 2022 — Combined Vitamin D, Omega-3 Fatty Acids, and a Simple Home Exercise Program May Reduce Cancer Risk Among Active Adults Aged 70 and Older: A Randomized Clinical Trial; “Double-blind, randomized-controlled trial…2,157 participants… 2000 IU/day of vitamin D₃, and/or 1 g/day of marine omega-3s, and/or a simple home strength exercise (SHEP) programme compared to placebo and control exercise… Supplementation with daily high-dose vitamin D₃ plus omega-3s, combined with SHEP, showed cumulative reduction in… cancer…” — Heike A. Bischoff-Ferrari et al, Frontiers in Aging link

61. Mar 2021 — Higher Mushroom Consumption Is Associated with Lower Risk of Cancer: A Systematic Review and Meta-Analysis of Observational Studies — Djibril M Ba, et al, PubMed link

62. Feb 19, 2019 — Vitamin K: Double Bonds beyond Coagulation Insights into Differences between Vitamin K1 and K2 in Health and Disease: “Vitamin K2 has been explored in several clinical interventions to supplement cancer treatments. In vitro studies found K2 supplementation alone to prevent growth and metastasis of multiple cancer cell lines. The mechanisms by which vitamin K2 can inhibit proliferation and metastasis of cancers has been reviewed elsewhere. In short, vitamin K2 may act in several pathways including protein kinase A, protein kinase C, nuclear factor kappa B and steroid and xenobiotic receptor. Furthermore, there are multiple cases by which K2 supplementation alongside standard treatment subsided cancer development, including multiple cases where patients entered complete remission. Remarkably vitamin K2’s action as an anticancer agent is not limited to a definitive cancer type, and instead has been reported in multiple cancer forms.” — Maurice Halder et al, International Journal of Molecular Sciences link

63. Mar 27, 2018 — Arctigenin Inhibits Liver Cancer Tumorigenesis by Inhibiting Gankyrin Expression via C/EBPα and PPARα; “Burdock (Arctium lappa) is a popular vegetable in China and Japan that is consumed for its general health benefits. The principal active component of burdock is arctigenin, which shows a range of bioactivities in vivo and in vitro. Here, we investigated the potential anti-tumor effects of arctigenin using two human hepatocellular carcinoma cell lines, HepG2 and Hep3B, and sought to elucidate its potential mechanisms of action… Our results suggested that arctigenin could inhibit liver cancer growth by directly recruiting C/EBPα to the gankyrin promoter. PPARα subsequently bound to C/EBPα, and both had a negative regulatory effect on gankyrin expression.” — Ying Sun et al, Frontiers in Pharmacology link

64. Feb 17, 2018 — Case Report of Unexpectedly Long Survival of Patient With Chronic Lymphocytic Leukemia: Why Integrative Methods Matter; “Nutritional supplementation along with lifestyle changes appears to have supported the maintenance of stable and indolent CLL in this patient.” — Gregory Haskin & Mikhail Kogan, Integrative Medicine: A Clinician’s Journal (IMCJ) link

65. Jul 7, 2017 — Efficacy of Metabolically Supported Chemotherapy Combined with Ketogenic Diet, Hyperthermia, and Hyperbaric Oxygen Therapy for Stage IV Triple-Negative Breast Cancer — Mehmet Salih İyikesici et al, Cureus link

66. 2017 — The Results of Our Alternative & Natural Treatments; “We treated with natural methods alone, choosing among methods with research-established cancer-disrupting effect, both oral and intravenous, dietary and supplemented, nutritional and herbal, having a preference for those with high patient tolerance and compatibility, and varying with individual needs and tolerance… Our success rate of 93% in steadfast patients following all protocols as recommended, from Stage I through early Stage IV is unprecedented and unequalled in both conventional and natural medicine in all clinics that report their results in detail as we do in this paper.” — Colleen Huber NMD, Naturopathic Medical Doctors of Arizona and NatureWorksBest Cancer Clinic link and link

67. May 2016 — Natural cures for breast cancer treatment; “This review has centered on the biochemical properties of Allium sativum, Echinacea, Curcuma longa, Arctium lappa, Camellia sinensis, Panax ginseng and Flax seed. Extracts and juices of Withania somnifera, Amoora rohituka, Dysoxylum binectariferum and Vaccinium macrocarpon, respectively also used as anti-breast cancer. The volatile oils and extracts of these herbs and plants inhibit the synthesis of mevalonate that lessen the tumor growth and cholesterol synthesis.” — Munazza Shareef et al, Saudi Pharmaceutical Journal link

68. Oct 6, 2015 — Chemopreventive Actions of Blond and Red-Fleshed Sweet Orange Juice on the Loucy Leukemia Cell Line; “The purpose of this study was to examine the cytotoxicity, cell cycle, apoptosis, and cytokine secretion after blond orange juice (BOJ), red-fleshed sweet orange juice (ROJ), and hesperidin (HSP) treatment of a novel T acute lymphoblastic leukemia cell line, Loucy… Taken together, these results suggest potential chemopreventive effects of BOJ and ROJ on Loucy cells.” — Grace Dourado et al, KoreaScience link

69. Jul 10, 2015 — Phytochemicals as Innovative Therapeutic Tools against Cancer Stem Cells; “Among chemopreventive dietary agents, the following are the most effective in reducing the proliferative activity of cancer cell lines: tea polyphenol epigallocatechin-3-gallate (EGCG), curcumin, resveratrol, lycopene, pomegranate extracts, luteolin, genistein, piperin, β-carotene and sulforaphane. These phytochemicals have been thoroughly studied for at least three decades. Indeed, research on phytochemicals began even before the potential role of cancer stem cells (CSCs) in tumor development and propagation was known. However, these studies provide a huge body of knowledge, which can now be applied in the development of treatments against CSCs.” — Emanuele-Salvatore Scarpa & Paolino Ninfali, International Journal of Molecular Sciences link

70. Dec 16, 2014 — Inhibitory effect of piperine on Helicobacter pylori growth and adhesion to gastric adenocarcinoma cells — Nagendran Tharmalingam et al, Infectious Agents and Cancer link

71. May 27, 2014 — Resveratrol–zinc combination for prostate cancer management — Chandra K. Singh et al, Cell Cycle link

72. Mar 7, 2024 —Vitamin D May Double Chances of Surviving Breast Cancer; “Researchers found that breast-cancer patients who had high levels of vitamin D were twice as likely to survive [as] women with low levels. They reviewed five studies that observed more than 4,440 women… Study co-author Dr. Heather Hofflich [is] an associate professor of medicine at the University of California San Diego.” — Eliana Dockterman, TIME Magazine link

73. Mar 1, 2014 — Anthocyanins: Targeting of Signaling Networks in Cancer Cells — Muserref Hilal Sehitoglu et al, Asian Pacific Journal of Cancer Prevention link

74. Feb 9, 2014 — Vitamin C 'gives chemotherapy a boost'; “High-dose vitamin C… has long been used as an alternative therapy for cancer. In the 1970s, chemist Linus Pauling reported that vitamin C given intravenously was effective in treating cancer. However, clinical trials of vitamin C given by mouth failed to replicate the effect, and research was abandoned. It is now known that the human body quickly excretes vitamin C when it is taken by mouth. However, scientists at the University of Kansas say that when given by injection, vitamin C is absorbed into the body, and can kill cancer cells without harming normal ones. The researchers injected vitamin C into human ovarian cancer cells in the lab, into mice, and into patients with advanced ovarian cancer. They found ovarian cancer cells were sensitive to vitamin C treatment, but normal cells were unharmed.” — Helen Briggs, BBC link

75. Dec 4, 2013 — Curcumin suppresses doxorubicin-induced epithelial-mesenchymal transition via the inhibition of TGF-β and PI3K/AKT signaling pathways in triple-negative breast cancer cells; "Doxorubicin [chemotherapy] treatment consequently acquires undesired malignance characteristics [i.e., EMT and multi-drug resistance]... Curcumin suppressed doxorubicin-induced EMT." — Wei-Chih Chen et al, Journal of Agriculutral and Food Chemistry link

76. Apr 1, 2013 — Rumor: New drug shrinks, cures all tumors; “Researchers say they have created a drug that has killed every kind of cancer tumor it has come in contact with, according to Science Magazine. The antibody treatment works by blocking a protein called CD47 which tricks the body into not destroying cancerous cells. After the protein is blocked, the body can then recognize the cancer cells as invaders and attack…. Weissman's research showed that blocking CD47 can cure more than just blood cancers. The drug can also shrink or cure human breast, ovary, colon, bladder, brain, liver and prostate tumors that have been transplanted into mice. The treatment forced the mice's immune system to kill the cancer cells. This means this single drug could cure a variety of cancers and prevent cancers from spreading in the body.” — MSN (No longer at original link; an excerpt is on WantToKnow here)

77. 2013 — Identification of Proapoptopic, Anti-Inflammatory, Anti-Proliferative, Anti-Invasive and Anti-Angiogenic Targets of Essential Oils in Cardamom by Dual Reverse Virtual Screening and Binding Pose Analysis; “This study revealed vital information about the poly-pharmacological anti-tumor mode-of-action of essential oils in cardamom.” — Biplab Bhattacharjee & Jhinuk Chatterjee, Asian Pacific Journal of Cancer Prevention link

78. Dec 10, 2012 — Zinc and breast cancer risk; “The studies have been performed on 3 independent groups: (1) 119 unselected breast cancer patients matched 1:1 with 119 unaffected controls (carriers of BRCA1 mutation have been excluded), (2) 99 breast cancer cases (serum collected at the moment of diagnosis, before treatment) and 198 matched 1:2 unaffected controls, (3):27 breast cancer cases (serum collected 1-2 years before diagnosis) and 53 controls matched 1:2. All individuals in groups (2) and (3) were carriers of BRCA1 mutation…. Serum zinc level is associated with breast cancer risk in BRCA1 carriers and noncarriers. Analysis of serum zinc concentration revealed tendency to increased risk of breast cancer for unselected breast cancers and BRCA1 carriers with zinc level <750±50 μg/L.” — Katarzyna Kaczmarek et al, Hereditary Cancer in Clinical Practice link

79. December 2012— The role of PKC isoforms in the inhibition of NF-κB activation by vitamin K2 in human hepatocellular carcinoma cells; “Vitamin K has diverse protective effects against osteoporosis, atherosclerosis and carcinogenesis.” —

    JingHe Xia et al, The Journal of Nutritional Biochemistry link

80. Sep 16, 2012 — Ursolic Acid Inhibits Growth and Metastasis of Human Colorectal Cancer in an Orthotopic Nude Mouse Model by Targeting Multiple Cell Signaling Pathways: Chemosensitization with Capecitabine — Sahdeo Prasad et al, Clinical Cancer Research link

81. Aug 10, 2011 — New leukemia treatment exceeds 'wildest expectations'; “In the research published Wednesday, doctors at the University of Pennsylvania say the treatment made the most common type of leukemia completely disappear in two of the patients and reduced it by 70 percent in the third. In each of the patients as much as five pounds of cancerous tissue completely melted away in a few weeks, and a year later it is still gone… The researchers removed certain types of white blood cells that the body uses to fight disease from the patients. Using a modified, harmless version of HIV, the virus that causes AIDS, they inserted a series of genes into the white blood cells. These were designed to make to cells target and kill the cancer cells. After growing a large batch of the genetically engineered white blood cells, the doctors injected them back into the patients. In similar past experimental treatments for several types of cancer the re-injected white cells killed a few cancer cells and then died out. But the Penn researchers inserted a gene that made the white blood cells multiply by a thousand fold inside the body. The white blood cells… relentlessly track[ed] down and kill[ed] the cancer cells in the blood, bone marrow and lymph tissue. As the white cells killed the cancer cells, the patients experienced the fevers and aches and pains that one would expect when the body is fighting off an infection, but beyond that the side effects have been minimal.” — Robert Bazell, NBC link

82. Feb 10, 2011 — Glucan-immunostimulant, adjuvant, potential drug; “The significant role of glucans in cancer treatment, infection immunity, stress reduction and restoration of damaged bone marrow has already been established. The present review focuses on the various less known but potentially significant roles glucans might play in medicine.” — Vaclav Vetvicka, World Journal of Clinical Oncology link

83. May 12, 2010 — DCA Research Team Publishes Results of Clinical Trials; “The… generic drug Dichloroacetate (DCA) may hold promise as potential therapy for perhaps the deadliest of all human cancers: a form of brain cancer called glioblastoma.” — Dr. Evangelos Michelakis, University of Alberta link

84. Mar 25, 2010 — Naturally occurring K vitamins inhibit pancreatic cancer cell survival through a caspase-dependent pathway; “Naturally-occurring, non-toxic K vitamins can inhibit the survival of some pancreatic cancer cell lines.” — Shayna L Showalter et al, Journal of Gastroenterology and Hepatology link

85. Feb 22, 2010 — In Tests, Vitamin D Shrinks Breast Cancer Cells; “Research… shows that the vitamin can kill human cancer cells… JoEllen Welsh, a researcher with the State University of New York at Albany, has studied the effects of vitamin D for 25 years. Part of her research involves taking human breast cancer cells and treating them with a potent form of vitamin D. Within a few days, half the cancer cells shriveled up and died. Welsh said the vitamin has the same effect as a drug used for breast cancer treatment. ‘Vitamin D enters the cells and triggers the cell death process,’ she [said]… The vitamin's effects were even more dramatic on breast cancer cells injected into mice. After several weeks of treatment, the cancer tumors in the mice shrank by an average of more than 50 percent. Some tumors disappeared. Similar results have been achieved on colon and prostate cancer tumors in mice.” — ABC News link

86. Apr 6, 2009 — Dietary Sulforaphane-Rich Broccoli Sprouts Reduce Colonization and Attenuate Gastritis in Helicobacter pylori–Infected Mice and Humans; “Helicobacter pylori infections… are strongly associated with the worldwide pandemic of gastric cancer.” — Akinori Yanaka et al, Cancer Prevention Research link

87. 2009 — Molecular Basis for Cancer Chemoprevention by Green Tea Polyphenol EGCG — Hirofumi Tachibana, Food Factors for Health Promotion (Karger) link

88. Dec 1, 2007 — Vitamin K2-induced cell growth inhibition via autophagy formation in cholangiocellular carcinoma cell lines; “Vitamin K2 (MK4) has antitumor effects on various types of cancer cell lines in vitro, and its efficacy has also been reported in clinical applications for patients with leukemia, myelodysplastic syndrome, and hepatocellular carcinoma (HCC).” — Masanobu Enomoto et al, International Journal of Molecular Medicine link

89. Nov 2, 2007 — Nanotubes seen as new weapon in cancer fight; “Houston researchers are using [carbon] nanotubes heated by radio waves to kill cancer cells. In a paper posted online by the journal Cancer, a team at the University of Texas M.D. Anderson Cancer Center and Rice University reported that the technique destroyed liver cancer tumors in rabbits and caused no side effects… The therapy marries two disparate disciplines: the relatively ancient field of radio waves and nanotechnology, the cutting-edge science of the ultra-small. The rabbit study found the therapy worked only when the two were used together. It works not by poisoning but by creating a localized hyperthermia or small fever that destroys the cancer cells' membranes, protein and even DNA. The cells then die and are carried out of the body through normal kidney functions… The result, researchers said, was the thermal destruction of 100 percent of the tumors.” — Houston Chronicle link and link

90. Feb 22, 2007 — Buzz for a Potential New Cancer Drug; “Dichloroacetate, or DCA, [is] a drug that kills cancer cells by exploiting a fundamental weakness found in a wide range of solid tumors.” — Jerry Adler, Newsweek link

91. May 9, 2006 — Injected Cells Cure Tumors in Mice; “White blood cells from mice that are naturally immune to cancer cured tumors in other mice and provided them with lifelong immunity to the disease, researchers reported.” — Thomas H. Maugh II, Los Angeles Times link

92. Feb 8, 2006 — Intracellular signaling network as a prime chemopreventive target of (–)-epigallocatechin gallate; “Chemoprevention is [the use of substances]… to intervene in the progress of carcinogenesis [creation of cancer cells]… Epigallocatechin gallate (EGCG), a principal antioxidant derived from green tea, is one of the most extensively investigated chemopreventive phytochemicals. EGCG has been known to block each stage of carcinogenesis…” — Hye-Kyung Na & Young-Joon Surh, Molecular Nutrition & Food Research link

93. Aug 15, 2003— Nonradioactive iodide effectively induces apoptosis in genetically modified lung cancer cells; “A therapeutic dose of nonradioactive iodide [iodine] has potent efficacy and high selectivity against lung cancer…” —Ling Zhang et al, Cancer Research link and link

94. Sep 16, 1997 — Broccoli sprouts: An exceptionally rich source of inducers of enzymes that protect against chemical carcinogens; “Large quantities of inducers of enzymes that protect against carcinogens can be delivered in the diet by small quantities of young crucifer sprouts (e.g., 3-day-old broccoli sprouts) that contain as much inducer activity as 10–100 times larger quantities of mature vegetables.” — Jed W. Fahey et al, PNAS link

95. Mar-Apr 1995 — The influence of zinc on apoptosis; “These conclusions should alert pharmacologists and physicians to the potential therapeutic applications of zinc compounds and zinc chelators in clinical disorders and diseases that involve apoptosis.” — F.W. Sunderman Jr., Annals of Clinical Laboratory Science link

96. 1971 — Hemoglobin Synthesis in Murine Virus-Induced Leukemic Cells In Vitro: Stimulation of Erythroid Differentiation by Dimethyl Sulfoxide — Charlotte Friend et al, PNAS link “One of the nation’s top virologists accidentally discovered that if DMSO was given to leukemic cells (specifically erythroblasts—which cause a relatively rare type of cancer), at a 2% concentration, it caused most of them to differentiate back to normal cells (which took up to 5 days), at 3% it stopped their growth, and at 5% it killed them.” [source]

97. May 18, 1940 — New Cancer Foe Hailed; “Germs that cause cancer have been discovered and with a new high-frequency radio ‘ray.’ They have been killed in human patients who then recovered, according to assertions made yesterday at the California State Homeopathic Medical society’s convention. The new progress in combating malignant cancer is said to have been made possible by an ultra microscope that magnifies 31,000 times and by a ray that kills micro-organisms in humans. Both the microscope and the ray were developed by Royal Raymond Rife of San Diego. Rife was to have announced his discoveries before the British Medical Society, but made the announcement locally because of the war. Dr. Arthur W. Yale of San Diego reported that with the aid of the Rife Ray he has succeeded in curing a number of cases of malignant cancer in which patients had been told they had only a limited time in which to live. The physician [said that] ‘for 17 years, Mr. Rife experimented with vibratory waves of all frequencies, and he has now succeeded in finding a rate that will kill the different invading organisms of the body. Radio waves, which with their harmonics range from 10 meters to 20,000 meters, are projected through a tube filled with helium gas. I have witnessed the disappearance of every malignant growth when the patient has remained under treatment.’ Dr. Yale then reported case histories of patients treated.” — Los Angeles Times [Link no longer active. Excerpt on WantToKnow here]

Research & Warning: Methylene Blue (Synthetic)

What it Is, How it Works, Contraindications

Methylthioninium chloride, widely known as methylene blue, is a synthetic liquid drug with a vibrant blue color. It contains various compounds, including carbon, chlorine, hydrogen, nitrogen, and sulfur… Since the 19th century, methylene blue has been used to treat carbon monoxide and cyanide poisoning, as well as… a rare condition that affects the blood’s ability to transport oxygen… Methylene blue improves mitochondrial energy metabolism by acting as an artificial electron carrier… Serious side effects may also occur, including drug interactions. Those [taking] SSRIs should avoid methylene blue… Methylene blue is unsafe for pregnant women as it has been linked to fetal harm and death. It also should be avoided while breastfeeding… Additionally, [do not] take methylene blue with a G6PD deficiency.

Dr. Eric Berg

Fully Synthetic Pharmaceutical

Methylene blue was the first fully synthetic pharmaceutical—developed in the late 1800s from coal tar, and deeply tied to the chemical dye industry that helped launch modern pharmaceutical manufacturing. Today, it’s resurfacing in biohacking and wellness spaces, but very few people are talking about the actual research behind it—or the serious risks… I invite you to join me with an open mind. I’ll walk you through its history, where it came from, how it’s supposed to work, and what the clinical literature actually says about its benefits and dangers.

Dr. Andrew Kaufman MD

“Lethal Neurotoxin, a Poison to the Brain”

In reality, methylene blue is a lethal neurotoxin, a poison to the brain. It has the same basic chemical composition and harmful clinical effects as the oldest and most neurotoxic “antidepressants,” the monoamine oxidase inhibitors (MAOIs). It also has similarities to the neurotoxic phenothiazine “antipsychotic” drugs, including the original Thorazine (chlorpromazine), but methylene blue is more stimulating or activating.

Dr. Peter Breggin MD & Ginger Breggin

1. Apr 11, 2025 — Methylene Blue Risks and Benefits: What the Medical Research Actually Says link

2. Apr 4, 2025 — From methylene blue and psychiatric drugs to pure evil — Dr. Peter Breggin MD & Ginger Breggin link

3. Feb 15, 2025 — METHYLENE BLUE in PANCREATIC CANCER – what we know so far; “Two small papers published in 2022 show Methylene Blue having a significant impact on Pancreatic Cancer cells. Unsurprisingly, both are behind paywalls. 2022 Biberoglu et al: “Methylene Blue decreased the growth and viability of pancreatic cancer cells in a dose- and time-dependent manner.” 2022 Almeida et al: “Our results demonstrated that Methylene Blue-PDT induced significant death of different human pancreatic ductal adenocarcinoma models representing two different susceptibility profiles.” It appears that pancreatic cancer cells are responsive to Methylene Blue whether it’s used alone or as part of PhotoDynamic Therapy. I’ve had tremendous success with Ivermectin and Fenbendazole in Pancreatic Cancer patients but it is worth exploring Methylene Blue in patients whose cancer doesn’t respond.” — Dr. William Makis MD link

4. Feb 12, 2025 — METHYLENE BLUE in BREAST CANCER – massive cancer cell killing achieved in this ground-breaking 2017 study; “Methylene Blue targets breast cancer cells but not normal breast cells… Triple Negative Breast Cancer cells are most sensitive to killing by Methylene Blue. Multiple cell killing mechanisms are at play but don’t involve mitochondria… Methylene Blue could be used as an adjunct to surgery to ‘eliminate microscropic residual malignant cells in the post-surgical tumor bed and prevent local as well as metastatic recurrence without affecting normal tissues.’ Methylene Blue Photodynamic Therapy could replace Radiation Treatment after breast cancer surgery.” — Dr. William Makis MD link

5. Aug 27, 2024 — Methylene Blue: Benefits, Uses, and Risks; “Evidence published in Frontiers in Pharmacology found that photodynamic anticancer therapy with methylene blue reduced tumor sizes in various types of cancer, including carcinoma, colorectal cancer, and melanoma.” — Dr. Eric Berg link

6. Jan 13, 2024 — Methylene Blue Metabolic Therapy Restrains In Vivo Ovarian Tumor Growth; “We investigated the potential of methylene blue (MB) as a metabolic therapy… for ovarian cancer. Our findings demonstrated a significant in vivo reduction in the proliferation of TOV112D-based ovarian-cell-line xenografts… These results revealed, for the first time, that MB specifically targets TOV112D mitochondria and probably induces cell apoptosis. The differential response of normal (ARPE-19) and cancer (TOV112D) cells to the MB treatment suggests potential alterations in cancer cell mitochondria, opening avenues for therapeutic approaches that target the mitochondria. Overall, our findings suggest the efficacy of MB as a possible treatment for ovarian cancer and provide valuable insights into the mechanisms underlying the efficacy of methylene blue metabolic therapy in ovarian cancer treatment.” — Jorgelindo da Veiga Moreira et al, Cancers (Basel) link

7. Sep 28, 2023 — Methylene blue in anticancer photodynamic therapy: systematic review of preclinical studies; “The results of the systematic review support the suggestions that photodynamic therapy with methylene blue helps against different types of cancer, including colorectal tumor, carcinoma, and melanoma.” — Amir Taldaev et al, Frontiers in Pharmacology link

8. Jul 12, 2022 — Advanced methylene blue – nanoemulsions for in vitro photodynamic therapy on oral and cervical human carcinoma; “Photodynamic therapy in vitro protocols applied to Oral Squamous Cell Carcinoma Cells and Cervical Cancer cells showed a decrease in cell viability through only one irradiation.” — Stephanie R. do Amaral et al, Lasers in Medical Science link

9. Jul 1, 2019 — Abstract 2958: Evaluating the therapeutic effects of methylene blue against prostate cancer; “Our initial analysis showed that Methylene Blue (MB) effectively reduced the viability of androgen-dependent (LNCaP) and androgen-independent (PC3 and DU145) Prostate cancer (PCa) cells… MB effectively targeted the PCa cell lines by inducing apoptotic cell death.” — Priyadarshini Thiruvalluvan Shanthi et al, Cancer Research link

10. November 2018 — Anticancer activity of methylene blue via inhibition of heat shock protein 70; “Methylene blue demonstrated potent anticancer activity.” — Dhaval Sanchala et al, Biomedicine & Pharmacotherapy link

11. Sep 1, 2018 — Reversing the Warburg Effect as a Treatment for Glioblastoma; “Glioblastoma multiforme (GBM) [a cancerous brain tumor], like most cancers, possesses a unique bioenergetic state of aerobic glycolysis known as the Warburg effect. Here, we documented that methylene blue (MB) reverses the Warburg effect… In summary, our current study demonstrated that MB exerts profound action on GBM bioenergetics. MB inhibits GBM cells proliferation and arrests the cell cycle in S phase. The effect of MB on GBM proliferation intertwined with the activation of AMPK and its downstream signaling of ACC and cyclin expression. Furthermore, our structure-activity relationship analysis indicated a direct link between the inhibitory action of MB on GBMs and its bioenergetic effects. By reversing the Warburg effect, MB switches the mitochondria from a biosynthetic hub to bioenergetic hub and inhibits GBM cell proliferation. Although the inhibitory action of MB on cancer proliferation needs further verification in vivo using different treatment paradigms, our in vitro data provide the proof of concept that reversal of Warburg effect might be a novel therapy for GBM.” — Ethan Poteet, et al, Journal of Biological Chemistry link

12. Mar 15, 2017 — Methylene blue photodynamic therapy induces selective and massive cell death in human breast cancer cells; “Methylene blue (MB-PDT) differentially induces massive cell death of tumour cells… Additionally, when using a physiological 3D culture model that recapitulates relevant features of normal and tumorous breast tissue morphology, we found that MB-PDT differential action in killing tumour cells was even higher than what was detected in 2D cultures.” — Ancely F. dos Santos et al, BMC Cancer link

13. No date — Methylene Blue in Advanced Prostate Cancer Care; “Methylene Blue disrupts mitochondria in cancer cells, leading to decreased energy production, inhibiting tumor growth. Methylene Blue therapy induces cell death in cancer cells, potentially leading to tumor regression… Smith et al (2018) [found that] Methylene Blue inhibited the growth of prostate cancer cells in a dose-dependent manner, with minimal toxicity to normal cells. Jones et al (2020) [found that] Methylene Blue induced apoptosis in advanced prostate cancer cells…” — Dr. Francisco Contreras, MD, Oasis of Hope Hospital link

Treatment Suppression: Verifiable Evidence

Healing modalities that don’t benefit industry are underutilized, suppressed, and disparaged. Providers who are perceived as a threat to establishment dictates or lucrative markets are condemned, intimidated and attacked.

Highlights

Oncology “Treatment” is Abysmal

The Warburg effect — Otto Warburg’s seminal observation that cancer cells preferentially ferment glucose into lactate even in oxygen-rich conditions — represents a metabolic vulnerability ripe as the perfect therapeutic target for cancer treatment. Yet, a century after its elucidation, oncology remains tethered to genetic paradigms, sidelining metabolic strategies in favor of cytotoxic [poisoning cells] and targeted interventions that work at best on about 15% of cancers, representing an abysmal “treatment” model.

2nd Smartest Guy in the World

“Cancer is big business”

Cancer is big business. It’s highly profitable.

The average cost of chemotherapy for a patient is probably $100,000.

-Dr. Paul Marik, author of “Cancer Care”

"If a Promising Compound Can't Be Patented, It's Highly Unlikely Ever to Make it to Market"

We could make faster progress against cancer by changing the way drugs are developed. In the current system, if a promising compound can't be patented, it is highly unlikely ever to make it to market no matter how well it performs in the laboratory. The development of new cancer drugs is crippled as a result... In 2004, Johns Hopkins researchers discovered that an off-the-shelf compound called 3-bromopyruvate could arrest the growth of liver cancer in rats. The results were dramatic; moreover, the investigators estimated that the cost to treat patients would be around 70 cents per day. Yet, three years later, no major drug company has shown interest in developing this drug. The hormone melatonin, sold as an inexpensive food supplement in the United States, has repeatedly been shown to slow the growth of various cancers when used in conjunction with conventional treatments. Early this year, another readily available industrial chemical, dichloroacetate, was found by researchers at the University of Alberta to shrink tumors in laboratory animals by up to 75 percent. However ... dichloroacetate is not patentable, and the lead researcher is concerned that it may be difficult to find funding from private investors to test the chemical. Potential anticancer drugs should be judged on their scientific merit, not on their patentability.

The New York Times, Patents Over Patients, Apr 1, 2007

Natural Treatments and Minimal Profit Cures Don't Get Approved

This film, Cancer: The Forbidden Cures, explains how it is virtually impossible for… inexpensive, natural treatments to receive government approval. The FDA requires extremely expensive clinical trials to demonstrate the efficacy of treatment, yet due to minimal profit in natural cures, trials will likely never be conducted, thus preventing approval of natural treatments, even if they do cure cancer. Even more problematic are those within the medical industry who have a vested interest in preventing alternative treatments from even gaining publicity, let alone approval. Chemotherapy drugs net billions of dollars in profits every year, fattening the wallets of physicians and drug company officers and stockholders. The respected American Medical Association (AMA) also reaps major profits from cancer medication advertisements and promotions. Few people are aware of the unsavory history of the AMA and its Journal of the American Medical Association (JAMA). This influential organization and its leaders became wealthy and powerful in the first half of the 20th century through selectively granting a seal of approval for untested drugs only to companies who would pay hefty fees to the AMA, and through major income from the tobacco industry for JAMA‘s promotions of cigarette smoking and its false claims about cigarette safety… The chief editor of JAMA [the publication of the American Medical Association] for 26 years, Morris Fishbein, worked tirelessly to prevent any potential cancer cure that was not under the control of the medical establishment from seeing the light of day. Fishbein… was actively involved in suppressing the alleged cancer cures in two of the five cases presented in this documentary, as well as many others not mentioned.

WantToKnow.info, Cancer Cures Video

When evidence began to emerge that petroleum-based medicines were causing cancer, Mr. Rockefeller founded the American Cancer Society through which he suppressed that information.

John D. Rockefeller Wiped Out Natural Cures to Create Big Pharma

_{2-min, John D. Rockefeller: Wiped Out Natural Cures to Create Big Pharma}

Evidence

1. No Date — Cancer Cures Video: Video Documentary Reveals Suppressed Cancer Cures [This link is to an article about the documentary, Cancer: The Forbidden Cures] — WantToKnow link

2. No Date — Cancer Cures Video; Cancer: The Forbidden Cures — WantToKnow 5-min video,20-min video, full 72-min video

3. Mar 25, 2025 — IVERMECTIN and FENBENDAZOLE Testimonial - Farmer with Diffuse Large B-Cell Lymphoma "everywhere" gets to "Cancer Free" with secret "smoothies" so Hospital staff wouldn't find out!; “This is what you have to do to survive as a Cancer patient in Canada, the United States, Australia, UK, Ireland, etc… ‘During the entire time he was in the hospital/rehab facilities, we were very discreet about providing him with the Ivermectin/Fenbendazole Protocol, mixing them into “smoothies”, so that staff wouldn’t know we were doing this.’ From ‘Lymphoma…was pretty much everywhere…largest mass was the size of a women’s basketball” to “PET Scan in December showed ZERO cancer’.” — Dr. William Makis MD link

4. Mar 1, 2025 — BREAKING NEWS: Alberta Government has FROZEN my Stripe Account, @X or Twitter income, Substack income, and GiveSendGo $199,370 Legal fundraiser. They are stealing all my sources of income. — Dr. William Makis MD link

5. Feb 17, 2025 — BREAKING NEWS: Dr.John Campbell and I were targeted, we were both hacked and locked out of our X (Twitter) accounts after our interview on Ivermectin and Fenbendazole in Cancer and Turbo Cancer — Dr. William Makis MD link

6. Feb 9, 2025 — NEWS: I was viciously attacked on my Ivermectin Testimonial of a 36 year old Pancreatic Cancer patient who is now Cancer Free. Who attacked me? A Pancreatic Cancer Support Group. — Dr. William Makis MD link

7. Jan 23, 2025 — EXCLUSIVE INTERVIEW – Sarah Westall Show – Cancer Cases Exploding & Authorities Persecute One of the World’s Top Cancer Doctors w/ Dr. William Makis (Dec.2024) — Dr. William Makis MD link

8. Jan 14, 2025 — Medical Industrial Complex Is Running DAMAGE CONTROL Over Mel Gibson’s Appearance On The Joe Rogan Show — 2nd Smartest Guy in the World link

9. Jan 6, 2025 — Is Big Pharma suppressing the truth about cancer? Survivor says ‘yes’; “Fourteen years ago, Suzy Griswold was diagnosed with thyroid cancer, but she didn’t take a traditional treatment route.” — Blaze Media link and 56-min video

10. Dec 29, 2024 — Ivermectin for Cancer?; “If you are unfortunate enough to be diagnosed with cancer and would like to try ivermectin for treatment, you’ll likely not find an oncologist who is willing to try it. They’ll probably lie and tell you it’s dangerous and will interfere with chemotherapy and radiation, even though the opposite is true… Americans are the most heavily medicated and vaccinated country in the world, yet we lead the world in chronic disease and have the lowest life expectancy of all modern countries. As you can see in this chart, we rank 48th! If all the medications and vaccines were effective, would we not be ranked higher and have fewer chronic diseases?” — The Truth Expedition link

11. Dec 27, 2024 — ‘Health’ mafia want to jail this heroic Canadian cancer doctor for 83 days; “I stood up for informed consent… Dr William Makis, an oncologist, speaks of his grim situation at the hands of fascist health bureaucrats who now want to jail him for standing up for medical ethics.” — Cairns News link

12. Dec 17, 2024 — IVERMECTIN ATTACKS continue: Confused about ivermectin? I don’t blame you, but it’s quite simple––just follow the money.; “Recently, there have been extreme and ongoing efforts to attack ivermectin, currently only available in an inexpensive, oral formulation, that reveal a telling pattern of shifting narratives designed to discredit it at any cost. The arguments appear less about genuine concerns and more about undermining a cheap, effective, and widely accessible treatment. Each argument presented seems to be grasping at straws, quickly losing traction and credibility, only to be replaced by another, equally tenuous claim. As efforts to undermine ivermectin intensify, these claims are understandably disturbing and confusing for people. Let’s have a brief look at what is being said.” — Tess Lawrie, MBBCh, PhD​ link

13. Dec 16, 2024 — Exposing “The Playbook” Big Pharma Uses To Silence Critics — The Jimmy Dore Show link

14. Nov 7, 2024 — Back by Popular Demand! ‘Cancer Care’ Second Edition Now Available: Dr. Paul Marik and the entire FLCCC Family want to thank everyone who fought to have this important medical research reinstated on Amazon after it was briefly removed in September 2024.— Independent Medical Alliance link

15. Jul 3, 2024 — Mammograms Are a Tragic Lie; “Research demonstrates this test does not reduce your risk of death from the disease. Mammograms, used to detect breast cancer, employ ionizing radiation that carries a risk of developing cancer… After 10 mammograms you have a 50% to 60% risk of receiving a false positive result, potentially necessitating further testing with more radiation or even treatment. You may be able to prevent 75% to 90% of breast cancers through lifestyle changes, such as reducing exposure to hazardous toxins, seeking out organic products, severely reducing refined sugar and fructose, and limiting protein.” [originally published Dec 20, 2017] — Dr. Joseph Mercola link

16. May 14, 2024 — Lawmaker Accuses Amgen of Placing Profits Above Patients with Dosing for a Cancer Drug; “A U.S. lawmaker is accusing Amgen of ‘putting profits before patients’ over its decision to continue marketing a high dose of a pricey cancer treatment instead of a lower dose that is less expensive and not as toxic to patients.” — Ed Silverman, STAT link

17. Mar 29, 2024 — Professor Exposes the Big Lie About Cancer; “Cancer is ‘all a big money game, and it’s dollars first, patient outcome second.’ – Dr. Thomas Seyfried, Professor of Biology… In Seyfried’s book, Cancer as a Metabolic Disease, he argues we should hit cancer where it hurts most by messing with its fuel supply, like using ketogenic diets to cut off the energy that cancer cells need. It’s a way of thinking about the disease that poses bad news to the profits of the cancer treatment industry.” — The Vigilant Fox link

18. Mar 29, 2024 — The Many Harms of Cancer-phobia; “Our fear of cancer is so fierce that it leads to choices that are… bad for our health… Consider the average-risk asymptomatic person who is younger or older than mammography or PSA screening is recommended for, but who, under the shadow of the fear of cancer, screens anyway, despite evidence that such screening is more likely to harm them than help, producing worrying false positives and in many cases leading to unnecessary treatment… An analysis done by the CDC for my book, Curing Cancer-phobia, How Risk, Fear, and Worry Mislead Us, found that in 2017, 21 million American women had cancer screening tests even though they were outside the age ranges for screening… Consider the harmful medical cascades that screening often triggers… all of which cause side effects that range from moderate to severe and… are essentially ‘fear-ectomies’, removing something that frightens the patient far more than it medically threatens them.” — David Ropeik, Sensible Medicine link

19. Jan 3, 2024 — The Cost of Unnecessary Testing in Health Care: The United States spends more than $300 billion annually on unnecessary medical treatment, including diagnostic testing.; “Excessive testing is… one part of… low-value health care, a term that refers to services that provide little or no benefit, cause potential harm, incur significant costs, or waste limited resources… The study, published in The American Journal of Medicine, focused on unnecessary testing… When patients have excessive diagnostic tests, the potential for errors exists. False positive or false negative test results can lead to a ‘diagnostic cascade’ of more testing or unnecessary prescriptions and harmful side effects… The United States health care system’s current structure rewards health care providers for providing more care, not necessarily the right care. In a fee-for-service system, providers make more money if they order more tests.” — Andrea Wickstrom, The Epoch Times link

20. Nov 1, 2023 — Joe Rogan Talks Fenbendazole and Cancer — 2nd Smartest Guy in the World link

21. Jun 19, 2023 — What Toxic Wildfires Can Teach Us About COPD and Covid-19; “One of my longtime theories (discussed further here) is that the pharmaceutical industry has an inherent conflict of interest against promoting any therapy that effectively treats a disease, as it destroys the franchise (perfectly demonstrated by this candid admission to investors from Goldman Sachs).” — A Midwestern Doctor, Mercola.com link

22. Mar 27, 2023 — The Life & Suppressed Work of Dr. Wilhelm Reich; “In the 1940′s the scientific works of Dr. Wilhelm Reich were presented to a world, marveled upon and then radically suppressed by industry and democratic government. A psychologist, scientist, mystic and refugee from Nazi persecution, Dr. Reich discovered ‘Orgone Energy’, or, life energy, a radiant blue glowing energy found in all living things, in high vacuums and in the open atmosphere… Many believe that his findings and experiments produced results that completely shattered the foundations of the energy and medical industries, and Dr. Reich himself was all too aware that he was deliberately targeted because of the threat he posed to big business. The establishment was so enraged by his discoveries… that in 1957 after FBI agents oversaw the destruction of his laboratory equipment, ‘six tons of his books, journals, and papers were burned in the 25th Street public incinerator in New York’s lower east side.'” — Harshita S, Medium link

23. Feb 14, 2023 — Your Money or Your Life: Patient on $50,000-a-Week Cancer Drug Fears Leaving Behind Huge Medical Debt; “After several rounds of treatment for a rare eye cancer — weekly drug infusions that could cost nearly $50,000 each — Paul Davis learned Medicare had abruptly stopped paying the bills… “Is it worth bankrupting my family for me to hang around for a couple of years?” Davis pondered… One of the hospitals that has administered the costly drug is appealing… But the uncertainty has compounded the stress of living with an aggressive cancer.” — Fred Schulte, KFF Health News link

24. Jun 2, 2022 — Doctors Sue FDA to Protect Ivermectin as Covid-19 Treatment; “Dr. Paul Marik… Dr. Mary Talley Bowden, and Dr. Robert L. Apter challenge the FDSA regarding ivermectin as a Covid treatment. The plaintiffs, ‘argue the FDA acted outside of its authority and illegally interfered with their ability to practice medicine by directing the public, including health professionals and patients, to not use ivermectin, a drug that has received full FDA approval for human use.'” — Independent Medical Alliance link

25. Jan 30, 2020 — 6 Bodily Tissues That can be Regenerated Through Nutrition; “Regenerative medicine threatens to undermine the very economic infrastructure that props up the modern, drug-based and quite candidly degenerative medical system. Symptom suppression is profitable because it guarantees both the perpetuation of the original underlying disease, and the generation of an ever-expanding array of additional, treatment-induced symptoms.”— Sayer Ji, Regenerate Project link

26. Apr 23, 2019 — Why The Law Forbids The Medicinal Use of Natural Substances; “According to the FDA’s legal definition, a drug is anything that ‘diagnoses, cures, mitigates, treats, or prevents a disease.’ The problem with this definition is that there are numerous substances, as readily available and benign as found on our spice racks, which have been proven by countless millennia of human experience to mitigate, prevent and in some cases cure disease, and which cannot be called drugs according to the FDA. How can this be? Well, the FDA has assumed for itself Godlike power, requiring that its official approval be obtained before any substance can legally be used in the prevention and treatment of disease. The FDA’s legal-regulatory control therefore is totalitarian and Napoleonic in construct; what it does not explicitly permit as a medicine is implicitly forbidden.” — Sayer Ji, GreenMedInfo (Waking Times) link

27. Apr 11, 2018 — Goldman Sachs asks in biotech research report: ‘Is curing patients a sustainable business model?’ — Tae Kim, CNBC link

28. Feb 17, 2018 — Case Report of Unexpectedly Long Survival of Patient With Chronic Lymphocytic Leukemia: Why Integrative Methods Matter; “The patient’s oncologist never discouraged her to take supplements. However, when the patient approached the oncologist for guidance on diet and supplements, the oncologist did not provide any recommendations, and moreover, expressed that diet and supplements are not going to alter her illness course. Although the patient learned how to navigate her care between 2 different providers, she often felt uneasy that her oncologist did not want to engage into any discussion about integrative approaches…. [This] underscores the dire need for field of oncology to embrace lifestyle strategies of managing indolent cancers by either adding these methods to the treatment toolbox or at least aggressively engaging into collaboration with integrative medicine providers, who often care for such patients. “ — Gregory Haskin & Mikhail Kogan, Integrative Medicine: A Clinician’s Journal (IMCJ) link

29. Aug 17, 2016 — Rockefeller: How He Changed The Idea Of Medicine And Everyday Cures: Big Pharma Was Invented By The Rockefeller’s; “The bitter truth is that when you go to your Western doctor, you are seen as a potential market for the medical factory’s products. For big pharma, there is no financial incentive to heal you, because a patient cured is a customer lost. Even if you are not sick, big pharma is still targeting you, trying to convince you that you are ill so that you will try its latest pill.” — Baxter Dmitry, Question Everything link

30. Apr 1, 2015 — Dr Peter Gøtzsche exposes big pharma as organized crime; “Peter C. Gøtzsche, MD is a Danish medical researcher… He has written numerous reviews within the Cochrane collaboration. Dr. Gøtzsche has been critical of screening for breast cancer using mammography, arguing that it cannot be justified. His critique stems from a meta-analysis he did on mammography screening studies and published as Is screening for breast cancer with mammography justifiable? in The Lancet in 2000. In it he discarded 6 out of 8 studies arguing their randomization was inadequate… In 2012 his book Mammography Screening: Truth, Lies and Controversy was published.” — Dr. McDougall Health & Medical Center, YouTube 8-min video

31. Feb 9, 2014 — Vitamin C 'gives chemotherapy a boost'; “High-dose vitamin C… has long been used as an alternative therapy for cancer. In the 1970s, chemist Linus Pauling reported that vitamin C given intravenously was effective in treating cancer… Sscientists at the University of Kansas say that when given by injection, vitamin C is absorbed into the body, and can kill cancer cells without harming normal ones. The researchers injected vitamin C into human ovarian cancer cells in the lab, into mice, and into patients with advanced ovarian cancer. They found ovarian cancer cells were sensitive to vitamin C treatment, but normal cells were unharmed… ‘Because vitamin C has no patent potential, its development will not be supported by pharmaceutical companies,’ said lead researcher Qi Chen. ‘We believe that the time has arrived for research agencies to vigorously support thoughtful and meticulous clinical trials with intravenous vitamin C.’" — Helen Briggs, BBC link

32. Aug 10, 2011 — New leukemia treatment exceeds 'wildest expectations'; “In the research published Wednesday, doctors at the University of Pennsylvania say the treatment made the most common type of leukemia completely disappear in two of the patients and reduced it by 70 percent in the third. In each of the patients as much as five pounds of cancerous tissue completely melted away in a few weeks, and a year later it is still gone… So why has this remarkable treatment been tried so far on only three patients? Both the National Cancer Institute and several pharmaceutical companies declined to pay for the research. Neither applicants nor funders discuss the reasons an application is turned down.” — Robert Bazell, NBC link

33. Aug 19, 2009 — Gardasil Researcher Speaks Out; “Dr. Diane Harper says young girls and their parents should receive more complete warnings before receiving the vaccine to prevent cervical cancer... It’s highly unusual for a researcher to publicly criticize a medicine or vaccine she helped get approved. Dr. Harper joins a number of consumer watchdogs, vaccine safety advocates, and parents who question the vaccine’s risk-versus-benefit profile.” — Sharyl Attkisson, CBS News link

34. Apr 1, 2007 — Patents Over Patients; "Researchers discovered that an off-the-shelf compound called 3-bromopyruvate could arrest the growth of liver cancer in rats. The results were dramatic; moreover, the investigators estimated that the cost to treat patients would be around 70 cents per day. Yet, three years later, no major drug company has shown interest in developing this drug. The hormone melatonin, sold as an inexpensive food supplement in the United States, has repeatedly been shown to slow the growth of various cancers when used in conjunction with conventional treatments. Early this year, another readily available industrial chemical, dichloroacetate, was found by researchers at the University of Alberta to shrink tumors in laboratory animals by up to 75 percent." — Ralph W. Moss, The New York Times link

35. May 18, 1940 —New Cancer Foe Hailed; “The new progress in combating malignant cancer is said to have been made possible by an ultra microscope that magnifies 31,000 times and by a ray that kills micro-organisms in humans. Both the microscope and the ray were developed by Royal Raymond Rife of San Diego. Rife was to have announced his discoveries before the British Medical Society, but made the announcement locally because of the war. Dr. Arthur W. Yale of San Diego reported that with the aid of the Rife Ray he has succeeded in curing a number of cases of malignant cancer in which patients had been told they had only a limited time in which to live. The physician [said that] ‘for 17 years, Mr. Rife experimented with vibratory waves of all frequencies, and he has now succeeded in finding a rate that will kill the different invading organisms of the body. Radio waves, which with their harmonics range from 10 meters to 20,000 meters, are projected through a tube filled with helium gas. I have witnessed the disappearance of every malignant growth when the patient has remained under treatment.’ Dr. Yale then reported case histories of patients treated. Mr. Rife alluded to the fact that the medical profession has not yet accepted his findings. ‘My work may not be accepted during my lifetime,’ he said, ‘but ... I know it ultimately will be recognized.’” — Los Angeles Times [Link no longer active. Excerpt on WantToKnow here]

Context: Organized Curation

This article is a subset of a vast resource curation on the failure and corruption of establishment medicine. See here for the entire curation or select links below to focus on an individual subject.

1. Failed Health Outcomes — The U.S. spends nearly twice the per-capita amount on healthcare than the next highest spender, yet Americans are the most chronically ill, and rank 48th in life expectancy, among other countries. In addition, medical misdiagnosis causes permanent harm and death to 795,000 people every year.

2. Verifiably Corrupt — Establishment medicine as a system* is verifiably corrupt, serving the interests of industry — not health. (*Obviously, not every individual working in establishment medicine is unethical. Rather, the system that educated / indoctrinated them, and that sets policy, hires, pays, and promotes them is verifiably corrupted.)

3. Big Pharma & Biotech : Immoral Business Model — Corporations, by design, are beholden to profit above all else, acting as powerful entities that are “essentially psychopathic and without conscience.” Pharmaceutical and biotech companies are the utmost example of corporate psychopathy, demonstrating inhumanity in response to human suffering.

4. Not Evidence/Science-Based — The bulk of establishment medicine’s standard of care is not based on unbiased, reproducible science. (We prove it here.)

5. Regulatory & Professional Betrayal — Government agencies entrusted to regulate the field of medicine fail to do so. The majority of influential professional organizations such as the American Medical Association are corrupted by industry.

6. Harms, by Drug or Test — Establishment medicine providers routinely utilize diagnostic testing and “treatments” that cause harm (“adverse”, “side” effects). Get verifiable evidence of the harms, organized by drug, treatment, or test (mammograms, CT scans, antibiotics, statins, benzos, etc).

7. Failed Strategies & Procedures — The philosophies, strategies, and procedures used by establishment medicine are dysfunctional and irrational, including a focus on suppressing symptoms rather than understanding them. Providers do not seek to identify and resolve the root causes of illness, and diagnosis is simply an exercise in naming groupings of symptoms, disconnected from their purpose and message.

8. Root Causes of Illness — With knowledge of causal factors, true healing is possible. Quickly identify drugs, vaccines, and toxins that cause each illness or symptom (e.g. cancer, depression, infertility, kidney issues, seizure, etc). Use quick links to verify documented “side effects” and evidence of harm.

9. Stifling Treatments That Don’t Enrich Industry — Healing modalities that don’t benefit industry are underutilized, suppressed, and disparaged. Providers who are perceived as a threat to establishment dictates or lucrative markets are condemned, intimidated and attacked.

10. Suppressed Cancer Research — This curation of more than 130 clinical studies provides quick access to documented cancer reversal and recovery successes. Also includes evidence of suppression and disparagement of treatments that don’t benefit establishment medicine.

11. Cancer Reversal Testimonials — More than 200 medical and personal testimonials on cancer reversal and recovery successes.

12. The Significance of Legal Precedent — Legal precedent, breach of duty, and “standard of care” are significant factors in the state of the medical industry.

13. Alternatives & Considerations — Alternatives, considerations, and what you can do.