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Osteoporosis drugs caused "substantially reduced bone strength" and caused more microcracks in bone than the controls.

Osteoporosis drugs caused blood calcium levels to drop, digestion problems, internal bleeding, irregular heartbeat, bone fractures, and bone death.

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Shelly Thorn
May 10, 2025
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Bisphosphonates therapy [osteoporosis drugs] had no detectable mechanical benefit... Instead, its use was associated with substantially reduced bone strength.

Bone & Joint Research

Bone from bisphosphonate-treated fracture patients exhibited… more numerous and larger microcracks than both fracture and non-fracture controls. Furthermore, bisphosphonate-treated bone demonstrated reduced tensile strength.

Scientific Reports

Several hundred plaintiffs… accused Merck & Co of failing to adequately warn about the risks of thigh bone fractures associated with its osteoporosis drug Fosamax.

Reuters

Contents

  1. Context: Pharmaceutical Drug Harms

  2. Osteoporosis Drugs, Bisphosphonates

  3. Evidence of Harm

  4. Addressing Root Causes of Bone Weakness

  5. For Wellness Providers & Educators: Boost Your Impact — Premium Resources Just a Click Away from $19

  6. See Also

Context: Pharmaceutical Drug Harms

  1. Pharmaceuticals generally + overprescription — In a controlled trial with disabled elderly adults, doing nothing except terminating some of their prescriptions dropped the death rate by 53% compared to the control. “More than half of the patients were candidates for deprescribing. The most common criterion was inappropriately long use, followed by safety concerns, and lack of indication.”

  2. Acid blockers, PPIs, drugs for acid reflux, heartburn, GERD, gastric ulcer — PPIs increased cancer, heart disease, osteoporosis and bone fractures, chronic kidney disease, neurodegeneration including Alzheimer’s and dementia, all-cause mortality (death), B-12 deficiency, pneumonia, and infections. PPIs altered children’s gut microbiome, the foundation of immunity and health, and increased infections in children. Stomach acid is crucial for health.

  3. ADHD drugs, stimulants —Caused “long-lasting changes” in brain function “similar to those that occur with cocaine.” “There is no such thing as a Ritalin deficiency.” Harms from ADHD drugs are many, and effects from higher doses are severe. Get verifiable research and alternatives for resolving the underlying issues.

  4. Alzheimer’s, dementia, and Parkinson’s drugs — Alzheimer’s & dementia drugs are less effective than B vitamins. And they cause fluid build-up & bleeding in the brain and increased death. Parkinson’s drugs deplete nutrients needed for brain health. Parkinson’s symptoms can be reversed. Successful therapies promote brain autophagy, “the removal of old and damaged brain cells and the creation of new and healthy brain cells.”

  5. Antibiotics — “Like TNT for the body’s microbiome” and linked with kidney stones, infertility, miscarriage, birth defects. Since 70 to 80% of the immune system is in the gut, damage to gut health is damage to immune health. Review curated research + alternatives and considerations.

  6. Asthma, allergy & hay fever drugs, antihistamines — Antihistamines cause heart problems, cognitive impairment, seizures in kids. Asthma “med” caused depression, anxiety, aggression, suicides. “Common medications like diphenhydramine [called benadryl, other brand names] cross the blood-brain barrier, disrupting normal brain activity and lowering seizure thresholds in vulnerable children.”

  7. Blood pressure drugs — Allergies, Diabetes, Weight Gain, Sexual Dysfunction, Depression, Acute Kidney Injury, Lung Cancer, Abnormal Heart Rate, and More. Blood pressure-lowering drugs have not been shown to be effective; do not address the root cause(s) of hypertension; have been contaminated with cancer-causing agents; and cause harm (“side effects”).

  8. Chemotherapy, other cancer drugs, radiation — “Chemotherapy makes cancer worse.” “Chemotherapy doubled the number of cancer cells in the bloodstream and lungs.” “Omitting radiation from treatment did not have an effect on survival rates.” “Radiation therapy increases the risk of solid tumors.” Chemotherapy drugs harm the healthcare professionals who administer them.

  9. Diabetes drugs, metformin — Caused death, low blood pressure, slowed heart rate, reduced blood flow to brain & organs. 90% + of diabetes is reversible with diet but professionals push drugs that harm. Professionals avoid telling the simple truth about the effectiveness of low carb diets and push profitable drugs that cause harm. In 2023, the FDA approved more drugs to treat diabetes in children.

  10. Osteoporosis drugs, bisphosphonates (you’re here) — Caused “substantially reduced bone strength” and caused more microcracks in bone than the controls. Osteoporosis drugs caused blood calcium levels to drop, digestion problems, internal bleeding, irregular heartbeat, bone fractures, and bone death.

  11. Over the counter drugs (OTCs) — Tylenol: ADHD, autism, ulcers, GI issues, kidney disease, heart failure. Laxative given to children: rage, tics, insomnia, seizures. Ibuprofen: DNA damage, hypertension. Sunscreens? Nightmare. Prescription drugs cause great harm, but so do over-the-counter meds and personal care products. Get an organized curation of research and reports.

  12. Pain relievers, NSAIDs, opioids — Even at “safe doses,” opioids cause confusion, dependence, depression, increased pain sensitivity, diminished energy, and low sex drive. Consistent use of NSAIDs caused heart attacks. Doctors are not trained in pain management or addiction, but they prescribe dangerous, highly addictive drugs. Get an organized curation of research and reports, plus alternatives and considerations.

  13. Psychiatric drugs: antidepressants, SSRIs, anti-anxiety, benzos, other psychotropics — Anti-depressants cause suicidal thinking, violence, and homicide. Anti-anxiety drugs cause insomnia and anxiety. Anti-psychotic drugs cause agitation, psychosis and violence. This organized curation of research and reports makes it clear that the evidence of harm from psychotropic drugs is overwhelming. We also provide alternatives and considerations.

  14. Scans, radiology, & ultrasounds (e.g. mammograms, CT scans, X-rays) — Medical scans (CT scans, mammograms, etc) use ionizing radiation which damages DNA and causes cancer. Research and resource curation, including research showing that 1) mammograms do not reduce risk of death, and 2) a higher incidence of breast cancer was caused from mammography radiation.

  15. Seizure drugs, anticonvulsants, anti-epileptic drugs (AEDs) — Devastating effects, negatively impacting virtually every system of the body, including damage to blood vessels and reduction in all three types of blood cells. Seizure drugs caused liver failure and death in young people and in healthy adults. A long list of non-harming alternatives listed below, with links to research on their effectiveness.

  16. Sleeping pills, sedatives — Sleeping pills make you unconscious, not asleep. They impair the sleep cycle. They increase dementia, falls, and death. And they’re highly addictive. Sleeping pills deprive people of true sleep and they impede essential brain functions (which are causes of dementia, Alzheimer’s and other neurodegenerative diseases)

  17. Statins — Statin drugs damage health at foundational levels — mitochondria, muscles and nerves — which can lead to more than 300 health problems. Research curation on statin harms, plus research showing that 1) lowering cholesterol does not improve heart health, and 2) statins do not lower all-cause death rates.

  18. Steroids — Cause osteoporosis and double the risk of bone fractures. They increase heart failure, diabetes, psychiatric issues, glaucoma, and serious infections. Steroid users report rapid weight gain, intense hunger, irritability, anxiety, depression, sleep problems, acne, stomach pain, nausea, joint pain, and withdrawal reactions, among other adverse events.

  19. Vaccines — Reports by vaccine type.

  20. Weight loss drugs — Ozempic & Similar Weight Loss Drugs Cause Kidney Failure, Pancreatitis, Thyroid Cancer, Gallbladder Issues, Depression, Severe Stomach Problems, Bone & Muscle Loss, Blindness, and Death. “Ozempic, similar weight loss drugs linked to 162 deaths in U.S.” Get an organized curation of research and reports, with quick links to verify sources.

Osteoporosis Drugs, Bisphosphonates

  • Osteoporosis drugs include Aclasta, Alendronate, Binosto, Bisphosphonates, Boniva, Cholecalciferol, Denosumab, Etidronate, Fosamax, Ibandronate, Pamidronate, Reclast, Risedronate, Selective Estrogen Receptor Modulators, Strontium, Teriparatide, Tiludronate, Zoledronate, Zoledronic Acid, and Zometa [source and source and source and source]

Evidence of Harm

  1. Osteoporosis drugs caused “substantially reduced bone strength” — Bisphosphonates therapy had no detectable mechanical benefit… Instead, its use was associated with substantially reduced bone strength.” See also: Osteoporosis drugs may make bones weaker; “Drugs used to treat weak bones in elderly patients suffering from osteoporosis may actually make them weaker, research suggests.” See also: Long-term effects of bisphosphonate therapy: perforations, microcracks and mechanical properties; “Bisphosphonates may oversuppress remodelling resulting in accumulation of microcracks… Bone from bisphosphonate-treated fracture patients exhibited… more numerous and larger microcracks than both fracture and non-fracture controls. Furthermore, bisphosphonate-treated bone demonstrated reduced tensile strength and Young’s Modulus.”

  2. Osteoporosis drugs caused blood calcium levels to drop, digestion problems, internal bleeding, irregular heartbeat, bone fractures, and bone death. — “Common side effects of [bisphosphonates] include headache, abdominal discomfort, dyspepsia [digestive disorder, stomach pain], nausea and hypocalcemia [low levels of calcium in blood]… Severe side effects… have included esophageal ulcer, gastrointestinal bleeding, atrial fibrillation [irregular heartbeat] and, with long-term treatment, osteonecrosis [bone death] of the jaw and… femoral [thigh bone] fractures.” See also: Why You Should Avoid Osteoporosis Medications; “Bisphosphonate drugs prescribed for osteoporosis have been shown to weaken bone and cause microcracks that heighten your risk for atypical bone fractures. Nutrients that are important for healthy bone growth and strength include vitamin D, vitamins K1 and K2, calcium, magnesium, collagen, boron and strontium… Research suggests the load needed to trigger bone growth in the hip is 4.2 times your bodyweight. Blood flow restriction training is an alternative that not only appears to have a beneficial effect on bone health, but is also viable for the elderly and those who can’t lift heavy weights.” See also: Bisphosphonate-induced Severe Hypocalcemia – A Case Report; “A 78-year-old woman… presented to emergency department with altered mental status. It turned out that her symptom was due to severe hypocalcemia [low blood calcium level] which was caused by intravenous zoledronate [bisphosphonate] treatment. She also had renal dysfunction… This case supports the need for evaluation of renal dysfunction, vitamin D deficiency and parathyroid gland dysfunction before bisphosphonate treatment and accurate monitoring of plasma calcium and creatinine levels. In addition, vitamin D and calcium supply during treatment with bisphosphonate is mandatory.”

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